在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADCY3 Antibody

  • 中文名稱:
    ADCY3兔多克隆抗體
  • 貨號:
    CSB-PA001339GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AC-III antibody; AC3 antibody; ADCY3 antibody; ADCY3_HUMAN antibody; adenylate cyclase 3 antibody; Adenylate cyclase antibody; Adenylate cyclase type 3 antibody; Adenylate cyclase type III antibody; Adenylyl cyclase 3 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 3 antibody; olfactive type antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ADCY3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
  • 基因功能參考文獻:
    1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID: 29921800
    2. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID: 28122017
    3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID: 25431134
    4. The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID: 25044758
    5. Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID: 24113161
    6. endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID: 22681560
    7. Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID: 23077041
    8. This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID: 21042317
    9. Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID: 21079816
    10. identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID: 12623444
    11. expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID: 12782409
    12. Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID: 17581954
    13. This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID: 17895882
    14. These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID: 19576885

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.
  • 數據庫鏈接:

    HGNC: 234

    OMIM: 600291

    KEGG: hsa:109

    STRING: 9606.ENSP00000260600

    UniGene: Hs.467898



主站蜘蛛池模板: 高清破外女出血av毛片| 免费毛片全部不收费的| 成人午夜又粗又硬又长| 国内精品免费久久久久软件| 在线观看无码av网站永久免费| 国产99在线 | 欧美| 99久久婷婷国产综合精品电影| 宅男66lu国产在线观看| 一区二区在线 | 国| 新版天堂资源中文8在线| 超碰人人超碰人人| 无码国产精品免费看| 手机看片精品国产福利| 亚洲人成人网站在线观看| 婷婷五月综合色视频| 日韩精品人妻系列一区二区三区 | 国产偷人妻精品一区| 亚洲日韩欧美一区久久久久我| 精品成人毛片一区二区| 丰满熟女人妻一区二区三| 日本免费视频| 99re久久资源最新地址| 欧美阿v高清资源在线| 熟妇人妻系列aⅴ无码专区友真希| 成人综合婷婷国产精品久久 | 国产av人人夜夜澡人人爽麻豆| 久久国产精品免费一区二区三区| 欧美 国产 亚洲视频| 国产高清在线精品一区二区三区| 蜜桃久久精品成人无码av| 成人免费无遮挡无码黄漫视频| 亚洲成av人片天堂网老年人| 亚洲国产成人精品无码区在线| 在线播放亚洲第一字幕| 日韩欧无码一二三区免费不卡| 在线精品亚洲第一区焦香| 无码h肉动漫在线观看| 国产亚洲精品久久久久5区| 亚洲最大无码av网站观看| 亚洲综合av一区二区三区| 刺激性视频黄页|