在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADCY3 Antibody

  • 中文名稱:
    ADCY3兔多克隆抗體
  • 貨號:
    CSB-PA241921
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, human fetal brain tissue, Primary antibody: CSB-PA241921(ADCY3 Antibody) at dilution 1/312.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AC-III antibody; AC3 antibody; ADCY3 antibody; ADCY3_HUMAN antibody; adenylate cyclase 3 antibody; Adenylate cyclase antibody; Adenylate cyclase type 3 antibody; Adenylate cyclase type III antibody; Adenylyl cyclase 3 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 3 antibody; olfactive type antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ADCY3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
  • 基因功能參考文獻:
    1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID: 29921800
    2. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID: 28122017
    3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID: 25431134
    4. The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID: 25044758
    5. Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID: 24113161
    6. endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID: 22681560
    7. Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID: 23077041
    8. This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID: 21042317
    9. Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID: 21079816
    10. identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID: 12623444
    11. expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID: 12782409
    12. Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID: 17581954
    13. This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID: 17895882
    14. These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID: 19576885

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.
  • 數據庫鏈接:

    HGNC: 234

    OMIM: 600291

    KEGG: hsa:109

    STRING: 9606.ENSP00000260600

    UniGene: Hs.467898



主站蜘蛛池模板: 四库影院永久国产精品| 99亚洲男女激情在线观看| 国语对白做受xxxxx在线中国| 久久超碰精品一夜七次郎| 另类亚洲小说图片综合区| 少妇熟女久久综合网色欲| 日本丶国产丶欧美色综合| 97精品人妻系列无码人妻| 日韩在线一区二区三区免费视频| 日韩人妻无码精品久久| 337p日本欧洲亚洲大胆69影院| 国产精品一区二区av不卡| 无码av中文字幕久久专区| 精品麻豆丝袜高跟鞋av| 牲交a欧美牲交aⅴ免费一| 亚洲日韩乱码中文无码蜜桃臀| 真人做人试看60分钟免费| 国产精品美女久久久网站动漫| 亚洲中文在线精品国产| 香港三日本三级少妇三级66| 成人免费无遮挡无码黄漫视频| 国产成人亚洲综合网站小说| 亚洲色www成人永久网址| 人妻大战黑人白浆狂泄| 宅男66lu国产在线观看| 国产成av人片久青草影院| 免费无码毛片一区二区三区a片 | 久久亚洲精品高潮综合色a片| 午夜精品电影你懂的| 国产亚洲精品久久久久久彩霞| 精品人妻无码一区二区色欲产成人| 国产精品你懂的在线播放| 综合久久久久6亚洲综合| 图片区小说区av区| 成人国产精品一区二区网站公司| 亚洲欧洲日本无在线码| 美女黄网站18禁免费看| 黄桃av无码免费一区二区三区| 欧美老妇牲交videos| 久久无码中文字幕免费影院| 两个人看的www免费视频中文|