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  4. Recombinant Human Acylglycerol kinase, mitochondrial (AGK)

Recombinant Human Acylglycerol kinase, mitochondrial (AGK)

  • 中文名稱：
    Recombinant Human Acylglycerol kinase, mitochondrial(AGK)
  • 貨號：
    CSB-YP706634HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Acylglycerol kinase, mitochondrial(AGK)
  • 貨號：
    CSB-EP706634HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Acylglycerol kinase, mitochondrial(AGK)
  • 貨號：
    CSB-EP706634HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Acylglycerol kinase, mitochondrial(AGK)
  • 貨號：
    CSB-BP706634HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Acylglycerol kinase, mitochondrial(AGK)
  • 貨號：
    CSB-MP706634HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AGK
  • Uniprot No.：
  • 別名：
    2610037M15Rik; 6720408I04Rik; Acylglycerol Kinase; Acylglycerol kinase mitochondrial; Acylglycerol kinase; mitochondrial; agk; AGK_HUMAN; AI465370; FLJ10842; hAGK; HsMuLK; MuLK; Multi substrate lipid kinase; Multi-substrate lipid kinase; Multiple substrate lipid kinase; RGD1562046
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 表達區域：
    1-422
  • 氨基酸序列
    MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
  • 基因功能參考文獻：
    1. The dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome. PMID: 28712724
    2. Identify AGK as a bona fide subunit of TIM22 providing an exciting and unexpected link between mitochondrial protein import and Sengers syndrome. PMID: 28712726
    3. Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker for human gliomas. PMID: 27574811
    4. We showed that AGK was over-expressed in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes of early-stage CSCC patients. AGK can be used as an independent prognostic marker for early-stage CSCC. PMID: 26662108
    5. Data suggest that acylglycerol kinase (AGK) has potential as a prognostic factor for overall survival in nasopharyngeal carcinoma (NPC). PMID: 26443540
    6. AGK promotes the proliferation and cell cycle progression of oral squamous cell carcinoma. PMID: 25872568
    7. miR-194 could reduce the phosphoinositide 3-kinase (PI3K)/AKT/FoxO3a signaling pathway by suppressing acylglycerol kinase (AGK) directly. PMID: 25960215
    8. findings provide new evidence that AGK plays an important role in promoting angiogenesis and providing resistance to apoptosis in hepatocellular carcinoma PMID: 25474138
    9. compare our findings to those in 21 previously reported AGK mutation-positive Sengers patients, confirming that Sengers syndrome is a clinically recognisable disorder of mitochondrial energy metabolism PMID: 25208612
    10. AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1. PMID: 24886245
    11. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy. PMID: 22864860
    12. AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell carcinoma, as well as in lung and breast cancer. PMID: 23676499
    13. study reports 2 families with Sengers syndrome and mutations in the acylglycerol kinase gene; 1 proband had abnormal mitochondria with citrate synthase crystals, associated with high citrate synthase activity; these pedigrees confirm that mutation of AGK is responsible for the severe neonatal presentation of Sengers syndrome PMID: 23266196
    14. This is the first mutation in AGK gene to be implicated in the development of isolated cataract. PMID: 22415731
    15. The loss of AGK led to a decrease of the adenine nucleotide translocator in the inner mitochondrial membrane in muscle. PMID: 22284826
    16. Recessive mutations in AGK cause mitochondrial DNA depletion PMID: 22277967
    17. Lack of the AGK causes Sengers syndrome PMID: 22284826
    18. identification and characterization of a novel lipid kinase that phosphorylates multiple substrates, MuLK PMID: 15252046
    19. The chiral specificity of diacylglycerol kinase alpha, zeta & epsilon mimics the substrate specificity, with MuLK being the least selective and the epsilon isoform of diacylglycerol kinase exhibiting the greatest selectivity. PMID: 18004883
    20. High Expression of acylglycerol kinase is associated with development and progression of prostate cancer. PMID: 19549252

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  • 相關疾病：
    Mitochondrial DNA depletion syndrome 10 (MTDPS10); Cataract 38 (CTRCT38)
  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
  • 蛋白家族：
    AGK family
  • 組織特異性：
    Highly expressed in muscle, heart, kidney and brain.
  • 數據庫鏈接：

    HGNC: 21869

    OMIM: 212350

    KEGG: hsa:55750

    STRING: 9606.ENSP00000347581

    UniGene: Hs.743318



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