在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Actin-related protein 2 (ACTR2)

In Stock
  • 中文名稱(chēng):
    Recombinant Human Actin-related protein 2 (ACTR2)
  • 貨號(hào):
    CSB-EP001248HU
  • 規(guī)格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    ACTR2
  • Uniprot No.:
  • 別名:
    Actin-like protein 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length
  • 來(lái)源:
    E.coli
  • 分子量:
    51.7 kDa
  • 表達(dá)區(qū)域:
    1-394aa
  • 氨基酸序列
    MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
  • 基因功能參考文獻(xiàn):
    1. We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects. PMID: 28599093
    2. this study identified roles for ARP2 and filopodia in human respiratory syncytial virus -induced cell motility, virus production, and cell-to-cell spread. PMID: 27926942
    3. Coronin3 can regulate gastric cancer (GC) invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis. PMID: 24918434
    4. Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions. PMID: 23212915
    5. Using molecular dynamics simulations and biochemical assays with recombinant Arp2/3 complex, we now show how phosphorylation of Arp2 induces conformational changes permitting activation. PMID: 22125478
    6. ARP2-mediated actin polymerization is regulated by phosphorylation of WASP protein. PMID: 12791263
    7. Coexpression of Arp2 and WAVE2 is correlated with poorer patient outcome. PMID: 16638851
    8. High mRNA levels of Arp2 were significantly associated with liver metastasis of colorectal cancer. PMID: 17459058
    9. Arp2-depleted Jurkat T lymphocytes exhibit defects in spreading on anti-CD3; Arp2-depleted Jurkats exhibit defects in ruffle assembly but not in assembly of mitotic linear protrusions. PMID: 18720401

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Cell projection. Nucleus.
  • 蛋白家族:
    Actin family, ARP2 subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 169

    OMIM: 604221

    KEGG: hsa:10097

    STRING: 9606.ENSP00000367220

    UniGene: Hs.643727



主站蜘蛛池模板: 2019久久久最新精品| 新狼窝色av性久久久久久| 亚洲日韩精品一区二区三区无码| 国产 | 欧洲野花视频欧洲1| 国产精品无码久久四虎| 国内精品久久久久久tv| 亚洲人成色4444在线观看| 国产精品亚洲精品日韩已满十八小| 尤物蜜芽国产成人精品区| 久久国产成人精品av| 漂亮人妻去按摩被按中出| 女乱高潮久久久久久爽爽| 蜜臀av片在线观看| 国产精品污www一区二区三区 | 日产精品久久久久久久| 欧美男生射精高潮视频网站| 国产成人无码a区视频| 午夜免费无码福利视频| 国产精品无码天天爽视频| 国产剧情国产精品一区| 两性色午夜视频免费播放| 先锋影音av最新资源网| 欧美老熟妇欲乱高清视频| 日本午夜免费啪视频在线 | 国产女人高潮叫床视频| 亚洲女人自熨在线视频| 亚洲精品无码伊人久久| 日日碰狠狠躁久久躁| 强开小婷嫩苞又嫩又紧视频韩国| 午夜性色福利在线视频福利| 99国精品午夜福利视频不卡| 国产成人无码a区在线观看导航| 女人被躁到高潮免费视频| 国产美女精品视频线播放| 无码国产伦一区二区三区视频| 欧美精品亚洲精品日韩专区va| 久久久亚洲精品av无码| 国产奶头好大揉着好爽视频| 日韩精品久久久肉伦网站| 日本欧美大码aⅴ在线播放| 国产免费又色又爽粗视频|