在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human ATP-sensitive inward rectifier potassium channel 8 (KCNJ8), partial

Recombinant Human ATP-sensitive inward rectifier potassium channel 8 (KCNJ8), partial

  • 中文名稱：
    人KCNJ8重組蛋白
  • 貨號：
    CSB-YP613604HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KCNJ8重組蛋白
  • 貨號：
    CSB-EP613604HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KCNJ8重組蛋白
  • 貨號：
    CSB-EP613604HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KCNJ8重組蛋白
  • 貨號：
    CSB-BP613604HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KCNJ8重組蛋白
  • 貨號：
    CSB-MP613604HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    KCNJ8; ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+ channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
  • 基因功能參考文獻：
    1. KCNJ8-S422L as pathogenic for J-wave syndromes failed to appropriately account for European population structure and the variant is likely benign, or (b) Ashkenazi Jews may be at significantly increased risk of J-wave syndromes PMID: 23632791
    2. We identified a de novo missense mutation encoding Kir6.1[p.Cys176Ser] in the patient. Kir6.1[p.Cys176Ser] channels exhibited markedly higher activity than wild-type channels, as a result of reduced ATP sensitivity. PMID: 24700710
    3. KATP channels are up-regulated with increasing age in human myometrium PMID: 23369859
    4. Data indicate that pharmacological KvLQT1 and KATP (Kir6.1) inhibition or silencing with siRNAs down-regulated alpha-ENaC expression. PMID: 22406554
    5. The KCNJ8-S422L variant was shown to be associated with both increased susceptibility to atrial fibrillation and early repolarization. PMID: 22562657
    6. results suggest that acting on the 3'-UTR of Kir6.1 and the coding region of SUR2B, methylglyoxal causes instability of Kir6.1 and SUR2B mRNAs, disruption of vascular K(ATP) channels, and impairment of arterial function PMID: 22972803
    7. Data suggest that Kir6.1 and M3 muscarinic receptor colocalize to detrusor caveolae; studies include tissue from both male and female subjects. PMID: 22410194
    8. The researchers report evidence that the KCNJ8 gene increases susceptiblity to the brugada syndrome and early repolarization syndrome. PMID: 22056721
    9. The mutations localized to Kir6.1's C-terminus, involved conserved residues and the pinacidil-activated K(ATP) current was decreased 45% to 68% for Kir6.1-E332del and 40% to 57% for V346I between -20 mV and 40 mV. PMID: 21836131
    10. Down-regulation of Kir6.1 and Kir6.2 expression in myometrium may contribute to the enhanced uterine contractility associated with the onset of labour. PMID: 21418633
    11. Interaction with caveolin-1 causes a shift the channel's sensitivity to its physiological regulator magnesium ADP (MgADP). PMID: 20624795
    12. These findings further implicate KCNJ8 as a novel J-wave syndrome susceptibility gene and a marked gain of function in the cardiac K(ATP) Kir6.1 channel secondary to KCNJ8-S422L as a novel pathogenic mechanism for J-wave syndromes. PMID: 20558321
    13. mammalian oocytes express K(ATP) channels. PMID: 20847183
    14. sequence variants in KCNJ8 is unlikely to contribute to variation in postural change in systolic blood pressure PMID: 19952277
    15. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling PMID: 19959479
    16. Assembly limits the pharmacological complexity of ATP-sensitive potassium channels PMID: 11825905
    17. cGMP/PKG-dependent processes participate in activating the ATP-regulated K(+) channel PMID: 12217870
    18. down-regulation of this channel may facilitate myometrial function during late pregnancy PMID: 12356945
    19. In corporal smooth muscle is composed of Kir6.1-Kir6.2 construct expressed with SUR2B.K(ATP) channel in corporal smooth muscle cells is composed of heteromultimers of Kir6.1 and Kir6.2 with the ratio of 3 : 1 or 4 : 0 and SUR2B. PMID: 12934053
    20. Kir6.1/KCNJ8 hasa a role in the pathogenesis of impaired coronary vasomotility that varies among various ethnic groups PMID: 12964027
    21. The effect of nicotine on Kir6.1 channels is mediated by the production of superoxides. PMID: 15821440
    22. Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions. PMID: 16820413
    23. Results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of coronary spastic angina. PMID: 16964409
    24. caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II PMID: 18663158
    25. Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile PMID: 18996111
    26. Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1. PMID: 19139106

    顯示更多

    收起更多

  • 相關疾病：
    Sudden infant death syndrome (SIDS); Hypertrichotic osteochondrodysplasia (HTOCD)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ8 subfamily
  • 組織特異性：
    Predominantly detected in fetal and adult heart.
  • 數據庫鏈接：

    HGNC: 6269

    OMIM: 239850

    KEGG: hsa:3764

    STRING: 9606.ENSP00000240662

    UniGene: Hs.102308



主站蜘蛛池模板： 中国china露脸自拍性hd| 华人在线亚洲欧美精品| 国产成人精品无码一区二区三区| 国产亚洲精aa在线观看| 制服丝袜中文字幕在线| 少妇放荡的呻吟干柴烈火动漫| 欧美成人h亚洲综合在线观看| 亚洲精品国产自在现线最新| 精品综合久久久久久98| 丁香五月亚洲综合在线| 亚洲综合狠狠丁香五月| 日本一卡2卡3卡4卡免费乱码网站| 美女视频黄频a美女大全| 国产精品无码久久久久成人影院| 99久久婷婷国产综合精品| 国产在线精品视频二区| 一本大道大臿蕉视频无码| 小罗莉极品一线天在线| 成年女人18级毛片毛片免费| 中文字幕亚洲精品乱码| 免费视频爱爱太爽了网站| 亚洲色欲色欲www在线丝| 欧美精品18videosex性欧美| 亚洲无人区午夜福利码高清完整版| 国产精品久久久久影院亚瑟| 无码人妻精品一区二区| 亚洲国产精品久久久久婷婷软件| 国产69精品久久久久孕妇| 天天夜碰日日摸日日澡性色av| 丰满少妇女裸体bbw| 精品国产一区二区av麻豆不卡| 亚洲国内成人精品网| 无码h肉动漫在线观看| 国产性猛交╳xxx乱大交| 亚洲另类欧美在线电影| 欧美人妻少妇精品久久黑人| 亚洲一区精品二人人爽久久| av无码国产在线观看岛国| 精品亚洲aⅴ在线无码播放| 亚洲熟女乱综合一区二区| 猫咪www免费人成网站无码|