在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNJ8 Antibody

  • 中文名稱:
    KCNJ8兔多克隆抗體
  • 貨號:
    CSB-PA012060GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    KCNJ8; ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+ channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human KCNJ8
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB ;1:500-1:2000
    IF 1:10-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
  • 基因功能參考文獻:
    1. KCNJ8-S422L as pathogenic for J-wave syndromes failed to appropriately account for European population structure and the variant is likely benign, or (b) Ashkenazi Jews may be at significantly increased risk of J-wave syndromes PMID: 23632791
    2. We identified a de novo missense mutation encoding Kir6.1[p.Cys176Ser] in the patient. Kir6.1[p.Cys176Ser] channels exhibited markedly higher activity than wild-type channels, as a result of reduced ATP sensitivity. PMID: 24700710
    3. KATP channels are up-regulated with increasing age in human myometrium PMID: 23369859
    4. Data indicate that pharmacological KvLQT1 and KATP (Kir6.1) inhibition or silencing with siRNAs down-regulated alpha-ENaC expression. PMID: 22406554
    5. The KCNJ8-S422L variant was shown to be associated with both increased susceptibility to atrial fibrillation and early repolarization. PMID: 22562657
    6. results suggest that acting on the 3'-UTR of Kir6.1 and the coding region of SUR2B, methylglyoxal causes instability of Kir6.1 and SUR2B mRNAs, disruption of vascular K(ATP) channels, and impairment of arterial function PMID: 22972803
    7. Data suggest that Kir6.1 and M3 muscarinic receptor colocalize to detrusor caveolae; studies include tissue from both male and female subjects. PMID: 22410194
    8. The researchers report evidence that the KCNJ8 gene increases susceptiblity to the brugada syndrome and early repolarization syndrome. PMID: 22056721
    9. The mutations localized to Kir6.1's C-terminus, involved conserved residues and the pinacidil-activated K(ATP) current was decreased 45% to 68% for Kir6.1-E332del and 40% to 57% for V346I between -20 mV and 40 mV. PMID: 21836131
    10. Down-regulation of Kir6.1 and Kir6.2 expression in myometrium may contribute to the enhanced uterine contractility associated with the onset of labour. PMID: 21418633
    11. Interaction with caveolin-1 causes a shift the channel's sensitivity to its physiological regulator magnesium ADP (MgADP). PMID: 20624795
    12. These findings further implicate KCNJ8 as a novel J-wave syndrome susceptibility gene and a marked gain of function in the cardiac K(ATP) Kir6.1 channel secondary to KCNJ8-S422L as a novel pathogenic mechanism for J-wave syndromes. PMID: 20558321
    13. mammalian oocytes express K(ATP) channels. PMID: 20847183
    14. sequence variants in KCNJ8 is unlikely to contribute to variation in postural change in systolic blood pressure PMID: 19952277
    15. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling PMID: 19959479
    16. Assembly limits the pharmacological complexity of ATP-sensitive potassium channels PMID: 11825905
    17. cGMP/PKG-dependent processes participate in activating the ATP-regulated K(+) channel PMID: 12217870
    18. down-regulation of this channel may facilitate myometrial function during late pregnancy PMID: 12356945
    19. In corporal smooth muscle is composed of Kir6.1-Kir6.2 construct expressed with SUR2B.K(ATP) channel in corporal smooth muscle cells is composed of heteromultimers of Kir6.1 and Kir6.2 with the ratio of 3 : 1 or 4 : 0 and SUR2B. PMID: 12934053
    20. Kir6.1/KCNJ8 hasa a role in the pathogenesis of impaired coronary vasomotility that varies among various ethnic groups PMID: 12964027
    21. The effect of nicotine on Kir6.1 channels is mediated by the production of superoxides. PMID: 15821440
    22. Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions. PMID: 16820413
    23. Results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of coronary spastic angina. PMID: 16964409
    24. caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II PMID: 18663158
    25. Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile PMID: 18996111
    26. Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1. PMID: 19139106

    顯示更多

    收起更多

  • 相關疾病:
    Sudden infant death syndrome (SIDS); Hypertrichotic osteochondrodysplasia (HTOCD)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ8 subfamily
  • 組織特異性:
    Predominantly detected in fetal and adult heart.
  • 數據庫鏈接:

    HGNC: 6269

    OMIM: 239850

    KEGG: hsa:3764

    STRING: 9606.ENSP00000240662

    UniGene: Hs.102308



主站蜘蛛池模板: 大肉大捧一进一出好爽视频| 亚洲欧美日韩综合久久久久久| 亚洲综合av在线在线播放| 成年美女黄网站色大片免费看| 久久国产精品成人影院| 色伊人亚洲综合网站| 成年性午夜无码免费视频| 区二区三区国产精华液区别大吗| 国产乱子伦精品无码码专区| 久久久久久亚洲精品| 97精品一区二区视频在线观看| 国产又黄又刺激又高潮的网站| 国产在线看片免费观看| 亚洲色无码播放| 国色天香中文字幕在线视频| 免费看成人欧美片爱潮app| 欧美一区二区三区性视频| 欧美大香线蕉线伊人久久| 亚洲一区二区| 九九九免费观看视频| 国产蝌蚪视频一区二区三区| 免费国产成人高清在线视频 | 啪一啪射一射插一插| 国产三级做爰在线播放| 久久国产成人精品国产成人亚洲| 日韩av无码社区一区二区三区 | 亚洲乱码日产精品bd在观看 | 成在线人免费无码高潮喷水| 久久综合97丁香色香蕉| 日本一区不卡高清更新二区| 成年美女黄网站色大片免费看| 精品无码人妻一区二区三区品| 成人做受视频试看120秒| 国内精品久久久久av福利秒拍 | 玩弄少妇人妻| 亚洲va综合va国产产va中文| 9lporm自拍视频区| 日韩少妇内射免费播放18禁裸乳 | 日日碰狠狠躁久久躁2023| 亚洲国产精品自在拍在线播放蜜臀| 天堂中文在线www天堂在线|