在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human AKT-interacting protein (AKTIP)

  • 中文名稱:
    Recombinant Human AKT-interacting protein(AKTIP)
  • 貨號:
    CSB-EP862043HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    AKTIP
  • Uniprot No.:
  • 別名:
    AKT interacting protein; AKT-interacting protein; AKTIP; AKTIP_HUMAN; FT 1; FT1; Fused toes homolog; Fused toes protein homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    49.1kDa
  • 表達區域:
    1-292aa
  • 氨基酸序列
    MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
  • 基因功能參考文獻:
    1. Results show that AKTIP co-purifies with A- and B-type lamins and partially co-localizes with lamins in interphase nuclei. In addition, AKTIP depletion lowers lamin A expression and induces senescence hallmarks including telomere homeostasis in human primary fibroblasts. PMID: 27512140
    2. results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. PMID: 27342216
    3. FTS is involved in EGFR-mediated repair of DNA damage induced by cisplatin in ME180 cells PMID: 27535835
    4. AKTIP interacts with telomeric DNA and is required for telomere maintenance. PMID: 26110528
    5. High fused toes homolog expression is associated with radioresistance in cervical cancer. PMID: 25151576
    6. FTS silencing reduced EMT and cell migration by EGF treatment. These results demonstrate a novel function for FTS in EGF-mediated EMT process. PMID: 24971934
    7. *AKTIP single nucleotide polymorphisms are not associated with late-onset depression patients compared to healthy elderly controls. PMID: 24022875
    8. Targeted inhibition of FTS led to the shutdown of key elemental characteristics of cervical cancer and could lead to an effective therapeutic strategy. PMID: 21424602
    9. These data unraveled the involvement of new oncoprotein FTS in cervical cancer which plays a central role in carcinogenesis. PMID: 20945372
    10. Demographic and clinical characteristics and AKT1 single markers and haplotypes, but not AKTIP polymorphisms or interactions between AKT1 and AKTIP, are associated with increased risk for suicidal behavior in bipolar patients. PMID: 20132317
    11. Ft1 protein interacts directly with PKB, enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1 PMID: 14749367
    12. These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族:
    Ubiquitin-conjugating enzyme family, FTS subfamily
  • 數據庫鏈接:

    HGNC: 16710

    OMIM: 608483

    KEGG: hsa:64400

    STRING: 9606.ENSP00000378152

    UniGene: Hs.380897



主站蜘蛛池模板: 国产一区二区女内射| 西西人体www44rt大胆高清| 久久久久蜜桃精品成人片公司| 久久久久国产a免费观看rela| 性人久久网av| 岛国4k人妻一区二区三区| 久精品视频在线观看免费| 亚洲女同一区二区| 亚洲日韩精品a∨片无码加勒比 | 久久久久久久久久久国产| 国产成人无码av在线影院| 国产成熟妇女性视频电影| 少妇被又大又粗又爽毛片久久黑人 | 老司机导航亚洲精品导航| 潮喷大喷水系列无码久久精品| 国产又色又爽又黄的免费 | 国产制服丝袜欧美在线观看| 色噜噜av男人的天堂| 国产精品日韩av在线播放| 亚洲香蕉网久久综合影视| 日本亚洲欧美综合在线| 人妻去按摩店被黑人按中出 | 国产免费一卡二卡三卡四卡| 自偷自拍亚洲综合精品麻豆| 无码任你躁久久久久久| 国产午夜成人av在线播放| 午夜精品久久久久久久四虎| 亚洲欲色欲香天天综合网| 中文国产成人精品久久不卡| 久在线精品视频线观看| 人人澡人人妻人人爽人人蜜桃麻豆| 少妇被又大又粗又爽毛片久久黑人| 久久无码专区国产精品s| 午夜福利一区二区三区高清视频| 日产精品卡2卡三卡乱码网址| 毛片免费视频观看| 99精品国产再热久久无毒不卡| 午夜人妻理论片天堂影院| 久久久国产乱子伦精品作者| 天堂а√在线中文在线新版| 国产精品成人一区二区不卡|