在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human AF4/FMR2 family member 4 (AFF4), partial

  • 中文名稱:
    Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial
  • 貨號(hào):
    CSB-YP890687HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial
  • 貨號(hào):
    CSB-EP890687HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial
  • 貨號(hào):
    CSB-EP890687HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial
  • 貨號(hào):
    CSB-BP890687HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial
  • 貨號(hào):
    CSB-MP890687HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AFF4
  • Uniprot No.:
  • 別名:
    AFF4; AF5Q31; MCEF; HSPC092; AF4/FMR2 family member 4; ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
  • 基因功能參考文獻(xiàn):
    1. The TAR central loop contacts the CycT1 Tat-TAR recognition motif (TRM) and the second Tat Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR complex despite not touching the RNA, explaining how it enhances TAR binding to the SEC 50-fold. PMID: 27731797
    2. AFF4 is positioned to make unexpected direct contacts with HIV Tat, and Tat enhances P-TEFb/CCNT1 affinity for AFF4. PMID: 23471103
    3. missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia) PMID: 25730767
    4. HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. PMID: 23251033
    5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300
    6. Through the bridging functions of Tat and AFF4, P-TEFb and ELL2 combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription. PMID: 20471948
    7. AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II. PMID: 20159561
    8. MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat-transactivation. PMID: 17389929
    9. Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF] PMID: 12065898

    顯示更多

    收起更多

  • 相關(guān)疾病:
    CHOPS syndrome (CHOPS)
  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    AF4 family
  • 組織特異性:
    Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17869

    OMIM: 604417

    KEGG: hsa:27125

    STRING: 9606.ENSP00000265343

    UniGene: Hs.519313



主站蜘蛛池模板: 欧美乱大交xxxxx疯狂俱乐部| 国产萌白酱喷水视频在线播放| 久久精品国产只有精品66| 2019国产品在线视频| 午夜精品久久久久久毛片| 校园春色~综合网| 国产又黄又潮娇喘视频在线观看 | 人人澡人摸人人添| 男女午夜猛烈啪啦啦视频| 午夜dv内射一区二区| 人人妻在人人| 天天做天天爱天天爽综合网| 中文字幕亚洲制服在线看| 久久无码精品一一区二区三区| 免费观看成人毛片a片| 国产精品vr专区| 亚洲精品一区二区丝袜图片| 国产一卡二卡三新区2022| 久久无码字幕中文久久无码| 中文字幕精品无码一区二区三区| 久久久国产99久久国产久麻豆 | 久99视频精品免费观看福利| 欧美乱强伦xxxx孕妇| 国产a在亚洲线播放| 亚洲精品第一国产综合境外资源 | 无码欧美黑人xxx一区二区三区| 无码综合天天久久综合网色吧影院 | 国内精品国语自产拍在线观看| 日本免费一区二区三区四区五区| 国内精品久久毛片一区二区 | 日韩人妻少妇一区二区| 亚洲不卡中文字幕无码| 亚洲理论在线a中文字幕| 天天爽天天爽天天片a| 伊人久久大香线蕉av色婷婷色| 国产a√精品区二区三区四区| 人妻少妇偷人无码视频| 欧美人与性动交α欧美精品| 中文字幕乱妇无码av在线| 美女视频黄的全免费视频网站| 久久久久久人妻精品一区|