在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AFF4 Antibody

  • 中文名稱:
    AFF4兔多克隆抗體
  • 貨號:
    CSB-PA890687LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: AFF4 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 127, 98, 39 kDa
      Observed band size: 39 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AFF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AFF4
  • 別名:
    AFF4 antibody; AF5Q31 antibody; MCEF antibody; HSPC092 antibody; AF4/FMR2 family member 4 antibody; ALL1-fused gene from chromosome 5q31 protein antibody; Protein AF-5q31 antibody; Major CDK9 elongation factor-associated protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human AF4/FMR2 family member 4 protein (77-334AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,AFF4 Antibody (CSB-PA890687LA01HU),的標記方式是Non-conjugated。對于AFF4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA890687LB01HU AFF4 Antibody, HRP conjugated ELISA
    FITC CSB-PA890687LC01HU AFF4 Antibody, FITC conjugated
    Biotin CSB-PA890687LD01HU AFF4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:2000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
  • 基因功能參考文獻:
    1. The TAR central loop contacts the CycT1 Tat-TAR recognition motif (TRM) and the second Tat Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR complex despite not touching the RNA, explaining how it enhances TAR binding to the SEC 50-fold. PMID: 27731797
    2. AFF4 is positioned to make unexpected direct contacts with HIV Tat, and Tat enhances P-TEFb/CCNT1 affinity for AFF4. PMID: 23471103
    3. missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia) PMID: 25730767
    4. HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. PMID: 23251033
    5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300
    6. Through the bridging functions of Tat and AFF4, P-TEFb and ELL2 combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription. PMID: 20471948
    7. AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II. PMID: 20159561
    8. MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat-transactivation. PMID: 17389929
    9. Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF] PMID: 12065898

    顯示更多

    收起更多

  • 相關疾病:
    CHOPS syndrome (CHOPS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    AF4 family
  • 組織特異性:
    Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
  • 數據庫鏈接:

    HGNC: 17869

    OMIM: 604417

    KEGG: hsa:27125

    STRING: 9606.ENSP00000265343

    UniGene: Hs.519313



主站蜘蛛池模板: 欧美毛多水多黑寡妇| 伦埋琪琪久久影院三级| 日韩av高清在线看片| 5个黑人躁我一个视频| 国产嫖妓一区二区三区无码| 日韩精品无码一本二本三本色| 非洲黑人性xxxx精品| 四虎免费最新在线永久4hu| 国产精品毛多多水多| 国产乱子影视频上线免费观看| 巨爆乳无码视频在线观看| 亚洲国产精品综合久久网各| 丁香婷婷综合久久来来去| 亚洲狠狠爱综合影院网页| 亚洲精品毛片一区二区三区| 亚洲第一aaaaa片| 国产成人精品福利网站| 国产沙发午睡系列999| 6080亚洲人久久精品| 无码人妻少妇色欲av一区二区| 国产av无码专区国产乱码| 四虎国产精品永久在线国在线| 国产成人精品一区二区视频| 国产办公室秘书无码精品99| 粗大的内捧猛烈进出| 中文字幕av一区二区三区人妻少妇| 漂亮人妻熟睡中被公侵犯中文版| 制服丝袜有码中文字幕在线| 亚洲精品偷拍影视在线观看| 99久热re在线精品99re8热视频 | 中文人妻av久久人妻水密桃| ww欧日韩视频高清在线| 被拉到野外强要好爽黑人| 精品国产美女福到在线不卡| 亚洲成年网站青青草原| 亚洲 欧美 影音先锋| 日韩人妻无码精品-专区| 欧美激情日韩精品久久久| 久久久噜噜噜久久熟女aa片| 少妇人妻精品无码专区视频| 国产精品国产三级国产专区53|