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  4. Recombinant Human 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

Recombinant Human 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

  • 中文名稱：
  • 貨號：
    CSB-YP2193HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP2193HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP2193HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP2193HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP2193HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CN37
  • Uniprot No.：
  • 別名：
    2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP; CNPase; EC 3.1.4.37; CNP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
  • 基因功能參考文獻：
    1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
    3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
    4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
    5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
    6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
    7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
    8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
    9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
    10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
    11. crystal structure of the catalytic fragment PMID: 15713463
    12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
    13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
    14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
    15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
    16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
    17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
    18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
    19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
    20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
    21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
    22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

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  • 亞細胞定位：
    Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    2H phosphoesterase superfamily, CNPase family
  • 數據庫鏈接：

    HGNC: 2158

    OMIM: 123830

    KEGG: hsa:1267

    STRING: 9606.ENSP00000377470

    UniGene: Hs.273621



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