在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CNP Antibody, FITC conjugated

  • 中文名稱:
    CNP兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA21939C0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CNP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CNP
  • 別名:
    2'' antibody; 2'3' cyclic nucleotide 3' phosphodiesterase antibody; 3''-cyclic-nucleotide 3''-phosphodiesterase antibody; CN37_HUMAN antibody; CNP 1 antibody; CNP antibody; CNP1 antibody; CNPase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 2',3'-cyclic-nucleotide 3'-phosphodiesterase protein (226-415AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
  • 基因功能參考文獻:
    1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
    3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
    4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
    5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
    6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
    7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
    8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
    9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
    10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
    11. crystal structure of the catalytic fragment PMID: 15713463
    12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
    13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
    14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
    15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
    16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
    17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
    18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
    19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
    20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
    21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
    22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族:
    2H phosphoesterase superfamily, CNPase family
  • 數據庫鏈接:

    HGNC: 2158

    OMIM: 123830

    KEGG: hsa:1267

    STRING: 9606.ENSP00000377470

    UniGene: Hs.273621



主站蜘蛛池模板: 亚洲成av人在线观看网站| 国产无遮挡又黄又爽在线视频| 无码中文字幕免费一区二区三区| 超薄丝袜足j好爽在线观看| 亚洲aⅴ天堂av天堂无码| 野花社区视频www官网| 日本熟妇色xxxxx日本免费看 | 国产天美传媒性色av出轨| 亚洲日韩一中文字暮av| 柠檬福利第一导航在线| 久久精品一区二区三区中文字幕| 亚洲人午夜射精精品日韩| 美女视频黄的全免费视频网站 | 亚洲日韩精品欧美一区二区| 精品欧美h无遮挡在线看中文| 极品少妇被猛得白浆直喷白浆小说| 青青草av国产精品| 日韩一欧美内射在线观看 | 裸体丰满白嫩大尺度尤物| 乱子伦视频在线看| 国产亚洲精品久久久久久久软件| 草草久久97超级碰碰碰| 大香网伊人久久综合网2018| 国产黄大片在线观看| 色五月五月丁香亚洲综合网| 国产精品人成在线播放新网站| 日本 精品 高清不卡| 特黄aaaaaaaaa毛片免费视频| 中文字幕亚洲乱码熟女一区二区| 综合精品欧美日韩国产在线| 国产又粗又猛又爽又黄的视频在线观看动漫 | 日本japanese丰满少妇| 精品人妻少妇嫩草av无码专区| 又大又粗又爽又黄的少妇毛片| 国产亚洲精品久久久闺蜜| 荫道bbwbbb高潮潮喷| 久久99精品久久久久婷婷暖| 日本高清中文字幕免费一区二区| 无码播放一区二区三区| 国产精品乱码一区二区三区| 亚洲人成无码网站18禁10|