在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CNP Antibody

  • 中文名稱:
    CNP兔多克隆抗體
  • 貨號:
    CSB-PA468752
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of MCF7 cells using CNPase Polyclonal Antibody
    • Western Blot analysis of various cells using CNPase Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CNP
  • 別名:
    2'' antibody; 2'3' cyclic nucleotide 3' phosphodiesterase antibody; 3''-cyclic-nucleotide 3''-phosphodiesterase antibody; CN37_HUMAN antibody; CNP 1 antibody; CNP antibody; CNP1 antibody; CNPase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CNPase.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
  • 基因功能參考文獻:
    1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
    3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
    4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
    5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
    6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
    7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
    8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
    9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
    10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
    11. crystal structure of the catalytic fragment PMID: 15713463
    12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
    13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
    14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
    15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
    16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
    17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
    18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
    19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
    20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
    21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
    22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族:
    2H phosphoesterase superfamily, CNPase family
  • 數據庫鏈接:

    HGNC: 2158

    OMIM: 123830

    KEGG: hsa:1267

    STRING: 9606.ENSP00000377470

    UniGene: Hs.273621



主站蜘蛛池模板: 又色又爽又高潮免费观看 | 欧美丰满大爆乳波霸奶水多| 成人毛片100免费观看| 亚洲 成人 无码 在线观看| 熟妇人妻无乱码中文字幕真矢织江| 婷婷五月开心亚洲综合在线| 色偷偷女人的天堂亚洲网| 成年女人免费视频播放体验区| 人妻无码一区二区三区 tv| 任你躁久久精品6| 夜色爽爽影院18禁妓女影院| 午夜在线观看免费线无码视频| 久久久久88色偷偷| 国产sm鞭打折磨调教视频| 很黄很色60分钟在线观看| 乌克兰少妇videos高潮| 日韩乱码人妻无码系列中文字幕| 国产高清不卡免费视频| 欧美黑吊大战白妞| 艳妇乳肉豪妇荡乳| 麻豆果冻国产剧情av在线播放| 国产成av人片久青草影院| 国产乱码一区二区三区| 久久精品女人天堂av| 亚洲综合精品第一页| 欧美三级在线播放线观看| 97色偷偷色噜噜狠狠爱网站 | 国模小黎自慰gogo人体| 色偷偷女人的天堂亚洲网| 欧美肥妇bwbwbwbxx| 国产又粗又硬又大爽黄老大爷| 人人人插人人费| 国产精品福利自产拍在线观看| 92国产精品午夜福利免费| 亚洲精品国产成人精品软件| 亚洲国产欧美在线人成大黄瓜 | 无码人妻aⅴ一区二区三区69岛| 人妻.中文字幕无码| 免费无码av片在线观看潮喷| 很色很爽很黄裸乳视频| 免费刺激性视频大片区|