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  4. Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase

Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase

  • 中文名稱：
    Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase
  • 貨號：
    CSB-YP804291GGQ
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase
  • 貨號：
    CSB-EP804291GGQ
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase
  • 貨號：
    CSB-EP804291GGQ-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase
  • 貨號：
    CSB-BP804291GGQ
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Gloydius halys Zinc metalloprotease-disintegrin halysase
  • 貨號：
    CSB-MP804291GGQ
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; Zinc metalloproteinase-disintegrin-like halysase; EC 3.4.24.-; Snake venom metalloproteinase; SVMP; Vascular apoptosis-inducing protein; VAP
  • 種屬：
    Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    183-610
  • 氨基酸序列
    SQSNLTPE QQRYLNAKKY VKLVMVADYI MYLKYDRNLT TVRTRMYDIV NVINVIYQRM NIHVALVGLE IWSNKDKFIL RSAADVTLKL FATWRETDLL KRKSHDNAQL LTGINFNGPT AGLGYLGGIC NPMYSAGIVQ DHNKIHHLVA IAMAHEMGHN LGIDHDKDTC TCGAKSCVMA GTLSCEASYL FSDCSRKEHQ AFLIKDMPQC ILKKPLKTDV VSPPVCGNYF VEVGEDCDCG SPATCRDSCC DAATCKLRQG AQCAEGLCCD QCRFKGAGTE CRAATDECDM ADLCTGRSAE CTDRFQRNGQ PCQNNNGYCY NGKCPIMTDQ CIALFGPNAA VSEDACFQFN LEGNHYGYCR KEQNTKIACE PQNVKCGRLY CIDSSPANKN PCNIYYSPGD EDKGMVLPGT KCADGKACSN GQCVDVNRAS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Strongly inhibits the collagen-induced human platelet aggregation (inhibition of alpha-2/beta-1 (ITGA2/ITGB1) integrin). Hydrolyzes the Aalpha-chain of fibrinogen, without cleavage of Bbeta- and gamma-chains. Degrades type IV collagen (but not types I, II and V), fibronectin and vitronectin and also integrins alpha-1/beta-1 (ITGA1/ITGB1) and alpha-5/beta/1 (ITGA5/ITGB1) (but not alpha-V/beta-3 (ITGAV/ITGB3) and alpha-V/beta-5 (ITGAV/ITGB5) integrins). Both metalloproteinase (peptidase M12B) and disintegrin-like domains (recombinantly expressed and named halydin) play characteristic roles to inhibit human platelet aggregation. Induces apoptosis and strongly inhibits proliferation of endothelial cells as well as adhesion of the cells to extracellular matrix proteins. The apoptosis is closely associated with activation of caspase-3 and decreased level of Bcl-X(L)/Bax. Apohalysase, which lacks metalloprotease activity, is also able to induce the apoptosis. Cleaves insulin B chain at '34-His-|-Leu-35', '37-Glu-|-Ala-38', '38-Ala-|-Leu-39', '39-Leu-|-Tyr-40', '40-Tyr-|-Leu-41', '47-Gly-|-Phe-48' and '48-Phe-|-Phe-49' bonds.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily
  • 組織特異性：
    Expressed by the venom gland.


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