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  4. Recombinant Drosophila melanogaster Sodium-dependent serotonin transporter (SerT), partial

Recombinant Drosophila melanogaster Sodium-dependent serotonin transporter (SerT), partial

  • 中文名稱：
    黑腹果蠅SerT重組蛋白
  • 貨號(hào)：
    CSB-YP021702DLU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅SerT重組蛋白
  • 貨號(hào)：
    CSB-EP021702DLU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅SerT重組蛋白
  • 貨號(hào)：
    CSB-EP021702DLU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅SerT重組蛋白
  • 貨號(hào)：
    CSB-BP021702DLU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅SerT重組蛋白
  • 貨號(hào)：
    CSB-MP021702DLU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SerT
  • Uniprot No.：
  • 別名：
    SerT; CG4545; Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Cocaine-sensitive serotonin transporter; dSERT1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.
  • 基因功能參考文獻(xiàn)：
    1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism PMID: 28665105
    2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT). PMID: 27638414
    3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT storage, and potentially for function of dSERT. PMID: 16470720
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
  • 組織特異性：
    Expression is specific to cell bodies in the ventral ganglion of the embryonic and larval nervous system.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG4545

    STRING: 7227.FBpp0072269

    UniGene: Dm.5365



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