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  4. Recombinant Drosophila melanogaster Sex determination protein fruitless (fru), partial

Recombinant Drosophila melanogaster Sex determination protein fruitless (fru), partial

  • 中文名稱：
    黑腹果蠅fru重組蛋白
  • 貨號：
    CSB-YP811586DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅fru重組蛋白
  • 貨號：
    CSB-EP811586DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅fru重組蛋白
  • 貨號：
    CSB-EP811586DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅fru重組蛋白
  • 貨號：
    CSB-BP811586DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅fru重組蛋白
  • 貨號：
    CSB-MP811586DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    fru
  • Uniprot No.：
  • 別名：
    fru; BTB-VI; CG14307; Sex determination protein fruitless
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body.
  • 基因功能參考文獻：
    1. We find four times more male-biased than female-biased genes in TRAP mRNAs from fru P1-expressing neurons. This suggests a potential mechanism to generate dimorphism in behavior PMID: 27247289
    2. Enhanced male-male courtship, a fru mutant "hallmark," disappears when fru-mutant males are raised in isolation; neural fru expression is induced by neural activities in the adult invites the supposition that Fru as a chromatin regulator mediates experience-dependent epigenetic modification, which underlies the neural and behavioral plasticity. [Review] PMID: 27880074
    3. results highlight two feed-forward regulatory mechanisms with both developmentally hardwired and olfactory receptor activity-dependent components that establish and maintain fru expression in ORNs PMID: 27093619
    4. This study found that a 1.5-2-kb genomic fragment located 4-6-kb upstream of the P1 promoter in D. subobscura but not that of D. melanogaster permits MOL formation in females. PMID: 25518733
    5. Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation. PMID: 24642956
    6. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development. PMID: 25483248
    7. A small subset of fruitless subesophageal neurons modulate early courtship in Drosophila. PMID: 24740138
    8. These data map specific aspects of Drosphila courtship behavior to the level of single fru isoforms and fru(+) cell types PMID: 24440391
    9. These findings suggest that Fru isoform diversity facilitates both redundancy and specificity in gene expression PMID: 24440396
    10. This study elucidates the different regulatory and DNA binding activities of three Fru male specific isoforms on a genome-wide scale and identifies genes regulated by these isoforms. PMID: 24074028
    11. Study shows that such fru(M) null males acquire the potential for courtship when grouped with other flies; they apparently learn to court flies with which they were grouped, irrespective of sex or species and retain this behavior for at least a week. PMID: 24439379
    12. The male courtship circuitry is the fruitless (fru) gene play a key role of courtship behaviour in Drosophila. PMID: 24052176
    13. Fru determines the level of masculinization of neurons by orchestrating the transcription of a set of downstream genes, which remain to be identified. PMID: 19012071
    14. This chapter reviews the role of fruitless and the neurons that express it in the regulation of courtship behavior. PMID: 21906537
    15. Male courtship is initiated by direct activation of fru-expressing neurons in the absence of a courtship target. PMID: 21315260
    16. Transgenic expression of an RNAi construct directed against male-specific fruitless (fru(M)) transcripts resulted in normal wing extension, but highly defective courtship song, with 58% of males failing to generate detectable courtship song. PMID: 20919857
    17. one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS PMID: 12524343
    18. mechanisms of enhancer-dependent regulation of alternative 5'-splice sites PMID: 12646561
    19. Phenotypic analyses and rescue experiments provide evidence that one of the sex-nonspecific functions of the fru gene is the maintenance of neuronal identity rather than establishment of a neuron's initial fate. PMID: 12672012
    20. Gal4 expression in neurites innervating male reproductive structures are hypothesized to be targets of fruitless function. PMID: 15211467
    21. spliced differently in males and females, determines male courtship behavior PMID: 15935764
    22. FruM proteins specify the neural substrates of male courtship PMID: 15959468
    23. Fru expression can produce a male-specific neural circuit, probably used during heterosexual courtship, by preventing cell death in identifiable neurons PMID: 16281036
    24. Distinctive reproductive behaviors of males and females are mediated by a common fru neural circuit. PMID: 16713940
    25. Complex behaviors can be controlled by the single fruitless locus through multiple isoforms regulating both developmental and physiological pathways in different neuronal substrates. PMID: 16753560
    26. Sex-specific splicing of the fruitless gene plays a critical role in determining who and how a fly fights, and whether a dominance relationship forms. PMID: 17115036
    27. dsx required for specifying a sexually dimorphic population of fru-expressing neurons in the mesothoracic ganglion PMID: 17716899
    28. fruitless and doublesex genes are both required in thoracic neurons to generate normal male lovesongs. PMID: 17925211
    29. Fru expression is absent when flies fight like females and present when flies fight like males, thereby beginning a separation between courtship and aggression among these neurons. PMID: 18042702

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in parts of the adult male brain associated with the courtship song and steps of the male courtship. Also expressed in the larval and pupal male mushroom body and optic lobe. Expressed in pupal female optic lobe.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG14307

    STRING: 7227.FBpp0290499

    UniGene: Dm.4626



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