Recombinant Drosophila melanogaster Protein Wnt-4 (Wnt4), partial

中文名稱：

黑腹果蠅Wnt4重組蛋白
貨號：

CSB-YP026137DLU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅Wnt4重組蛋白
貨號：

CSB-EP026137DLU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅Wnt4重組蛋白
貨號：

CSB-EP026137DLU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅Wnt4重組蛋白
貨號：

CSB-BP026137DLU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅Wnt4重組蛋白
貨號：

CSB-MP026137DLU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Wnt4
Uniprot No.：

P40589
別名：

Wnt4; Wnt-4; CG4698; Protein Wnt-4; dWnt-4
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis.
基因功能參考文獻(xiàn)：
1. At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells. PMID: 29370168
2. disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females. PMID: 27364467
3. Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila PMID: 26994311
4. dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche. PMID: 27019121
5. this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression. PMID: 24436419
6. Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila. PMID: 23912125
7. We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm. PMID: 22371299
8. In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning. PMID: 21772251
9. It works as a negative signal in neural connectivity. (review) PMID: 21089332
10. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. PMID: 11970894
11. DWnt4 antagonizes the polarizing effect of four-jointed PMID: 15986451
12. in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina PMID: 16369482
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亞細(xì)胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Wnt family
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG4698

STRING: 7227.FBpp0088345

UniGene: Dm.341