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  4. Recombinant Drosophila melanogaster Chromatin-remodeling complex ATPase chain Iswi (Iswi), partial

Recombinant Drosophila melanogaster Chromatin-remodeling complex ATPase chain Iswi (Iswi), partial

  • 中文名稱：
    黑腹果蠅Iswi重組蛋白
  • 貨號：
    CSB-YP634508DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Iswi重組蛋白
  • 貨號：
    CSB-EP634508DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Iswi重組蛋白
  • 貨號：
    CSB-EP634508DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Iswi重組蛋白
  • 貨號：
    CSB-BP634508DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Iswi重組蛋白
  • 貨號：
    CSB-MP634508DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Iswi
  • Uniprot No.：
  • 別名：
    Iswi; CG8625; Chromatin-remodeling complex ATPase chain Iswi; EC 3.6.4.-; CHRAC 140 kDa subunit; Nucleosome-remodeling factor 140 kDa subunit; NURF-140; Protein imitation swi
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis.
  • 基因功能參考文獻：
    1. the role of ISWI in the hnRNPshsromega interaction PMID: 28209301
    2. ISWI enables bi-directional transitions between two fundamentally different forms of chromatin. PMID: 26549447
    3. Insertion of flexible linkers at strategic sites in ISWI that disrupt a power stroke does not affect nucleosome sliding. PMID: 24113208
    4. In a purified system ISWI- and CHD1-type nucleosome remodelers have a clamping activity such that they not only generate regularly spaced nucleosome arrays but also generate constant spacing regardless of nucleosome density. PMID: 25733687
    5. The effect of H4 tail at lysine 16 acetylation on ISWI remodelling depends on the precise nature of the substrate. PMID: 24516652
    6. finding show all fundamental aspects of nucleosome-remodeling catalysis are contained within the compact ATPase domain of ISWI PMID: 23202585
    7. define two new, conserved and separate regulatory regions on Drosophila ISWI, termed AutoN and NegC, which negatively regulate ATP hydrolysis (AutoN) or the coupling of ATP hydrolysis to productive DNA translocation (NegC). PMID: 23143334
    8. This study revealed a novel conformation of an ISWI ATPase domain PMID: 22167269
    9. Loss of ISWI causes global defects in omega speckle organization. PMID: 21637796
    10. ISWI binds genes near their promoters causing specific alterations in nucleosome positioning at the level of the Transcription Start Site, and thus a role in higher eukaryote transcriptional regulation. PMID: 21448136
    11. ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses. PMID: 20194965
    12. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation PMID: 20008562
    13. ISWI recognizes an 'epitope' consisting of the DNA-bound H4 tail PMID: 11809876
    14. Histone acetylation reduces the ability of ISWI to interact with its substrate, couteracting chromatin compaction. PMID: 11882543
    15. ISWI is a 3'-5'-strand-specific, ATP-dependent DNA translocase that may be capable of forcing DNA over the surface of nucleosomes. PMID: 12612068
    16. Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI PMID: 14536084
    17. the roles of dom and iswi in germ line stem cell and somatic stem cell regulation PMID: 16322456
    18. Site-specific acetylation of Iswi by Gcn5. PMID: 17760996
    19. The chromatin remodeler Iswi directly represses Wg transcriptional targets. PMID: 18786525
    20. The work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers. PMID: 18922045
    21. Findings suggest that ISWI regulates higher-order chromatin structure by modulating the interaction of H1 with interphase chromosomes. PMID: 19380479

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family, ISWI subfamily
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG8625

    STRING: 7227.FBpp0086954

    UniGene: Dm.2581



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