在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Danio rerio Platelet-derived growth factor receptor alpha (pdgfra), partial

  • 中文名稱:
    斑馬魚pdgfra重組蛋白
  • 貨號:
    CSB-YP866765DIL
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    斑馬魚pdgfra重組蛋白
  • 貨號:
    CSB-EP866765DIL
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    斑馬魚pdgfra重組蛋白
  • 貨號:
    CSB-EP866765DIL-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    斑馬魚pdgfra重組蛋白
  • 貨號:
    CSB-BP866765DIL
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    斑馬魚pdgfra重組蛋白
  • 貨號:
    CSB-MP866765DIL
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    pdgfraPlatelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; EC 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor
  • 種屬:
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric pdgfa, homodimeric pdgfb, heterodimers formed by pdgfa and pdgfb or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between pdgfra and pdgfrb. Phosphorylates pik3r1, plcg1, and ptpn11. Activation of plcg1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates pik3r1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of hras and of the MAP kinases mapk1/erk2 and/or mapk3/erk1. Promotes activation of STAT family members stat1, stat3 and stat5a and/or stat5b. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
  • 基因功能參考文獻:
    1. Pdgf/Pdgfr signalling guides neural crest contribution to the haematopoietic stem cell specification niche. PMID: 28394883
    2. Untreated pdgfra mutants have cleft palate due to defective neural crest cell migration, whereas pdgfra heterozygotes develop normally. PMID: 23861062
    3. pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation PMID: 12128230
    4. The conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate. PMID: 18264099
    5. Protean differentiation and proliferation pathways are commonly regulated by PDGFRa, PDGFRb and PDGFRa/b while each receptor is also responsible for regulating unique signaling pathways. Some signaling is solely modulated through heterodimeric PDGFRa/b. PMID: 19030102

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection, cilium. Golgi apparatus.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲精品久久久蜜桃| 国产成人无码a区在线观看视频| 青春草在线视频观看| 久久人妻无码一区二区| 又色又爽又黄的吃奶视频免费观看| 成 人 社区在线视频| 午夜一区一品日本| 两性色午夜视频免费无码| 亚洲精品无码av人在线观看国产| 奇米影视7777狠狠狠狠色| 成人夜色视频网站在线观看| 大伊香蕉精品视频在线直播| 国产乱人伦无无码视频试看| 欧美亚洲日韩国产人成在线播放| 硬了进去湿好大娇喘视频| 国产精品午夜成人免费观看| 天天躁日日躁aaaaxxxx| 另类内射国产在线| 亚洲精品日本一区二区三区| 久久99精品久久久久久久不卡 | 亚洲熟妇无码av另类vr影视| 色欲来吧来吧天天综合网| www婷婷av久久久影片| 在线播放五十路熟妇| 亚洲成在人线av无码| 日日碰狠狠躁久久躁96| 国产精品亚洲mnbav网站| 亚洲人成色77777在线观看| 妺妺窝人体色www在线小说| 国产精品人成在线播放新网站| 国产女人喷潮视频在线观看| 色老板精品视频在线观看| 人人妻人人藻人人爽欧美一区| 久久亚洲精品成人无码网站夜色| 超清无码波多野吉衣中文| 亚洲www啪成人一区二区麻豆| 六月丁香婷婷色狠狠久久| 亚洲综合无码一区二区三区不卡| 无码av免费网站| 少妇三级全黄| 137裸交肉体摄影|