在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Clostridium botulinum Botulinum neurotoxin type F (botF), partial

  • 中文名稱:
    Recombinant Clostridium botulinum Botulinum neurotoxin type F(botF),partial
  • 貨號:
    CSB-YP341192CLQ
  • 規格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    botF
  • Uniprot No.:
  • 別名:
    botFBotulinum neurotoxin type F; BoNT/F; Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain; LC; EC 3.4.24.69); Botulinum neurotoxin F heavy chain; HC)]
  • 種屬:
    Clostridium botulinum
  • 蛋白長度:
    Partial
  • 來源:
    Yeast
  • 分子量:
    51.6kDa
  • 表達區域:
    1-436aa
  • 氨基酸序列
    MPVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPIDEFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFGSINIVTFSPEYEYTFNDISGGHNSSTESFIADPAISLAHELIHALHGLYGARGVTYEETIEVKQAPLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNLLDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDSIPDKGLVEKIVKFCKSVIPRK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. Whole toxin only has protease activity after reduction, which releases LC. Requires complex eukaryotic host polysialogangliosides for full neurotoxicity. It is not clear whether a synaptic vesicle protein acts as its receptor; there is evidence for and against SV2 fulfilling this function.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '60-Gln-|-Lys-61' bond of synaptobrevin-1/VAMP1 and the equivalent 'Gln-|-Lys' sites in VAMP2 and VAMP3. Cleaves the '48-Gln-|-Lys-49' bond of A.californica synaptobrevin (AC P35589).; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The RBD is responsible for the adherence of the toxin to the cell surface. It simultaneously recognizes 2 coreceptors; polysialated gangliosides and the receptor protein SV2A, SV2B and SV2C in close proximity on host synaptic vesicles; although not all evidence indicates these are the receptors. The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol.
  • 亞細胞定位:
    [Botulinum neurotoxin type F]: Secreted.; [Botulinum neurotoxin F light chain]: Secreted. Host cytoplasm, host cytosol.; [Botulinum neurotoxin F heavy chain]: Secreted. Host cell junction, host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 亚洲国产日韩在线人成蜜芽| 久久精品中文字幕一区二区三区| 樱花草在线社区www韩国| 免费观看四虎精品国产地址| 一个人看的视频www在线| 国产拍揄自揄免费观看| 国产成人av男人的天堂| 久久99国产亚洲高清观看首页| 成人做爰www网站视频| 免费又黄又裸乳的视频| 亚洲婷婷开心色四房播播| 欧美人与动性xxxxbbbb| 国产精品乱码高清在线观看| 5566先锋影音夜色资源站在线观看| 青春草在线视频免费观看| 亚洲mv国产mv在线mv综合试看 | 久久无码人妻丰满熟妇区毛片| 亚洲中文无码人a∨在线导航| 野外被强j到高潮免费观看| 国产在线视频主播区| 亚洲日韩aⅴ在线视频| 精品亚洲国产成av人片传媒| 亚洲日韩穿丝袜在线推荐| 国产精品综合av一区二区国产馆| 丝袜 中出 制服 人妻 美腿| 亚洲色播爱爱爱爱爱爱爱| 青青草国产精品免费观看| 风韵丰满熟妇啪啪区老老熟女百度| 97爱亚洲综合成人| 欧美成人看片一区二区三区尤物| 亚洲 丝袜 制服 欧美 另类 | 亚洲卡一卡二新区| 欧美超级乱婬视频播放| 青青国产线免观| 欧美成aⅴ人高清免费| 国产乱子伦60女人的皮视频| 成 年 人 黄 色 大 片大 全| 精品无人区一区二区三区在线| 在线看片免费人成视频影院看| 少妇被多人c夜夜爽爽| 92国产精品午夜福利|