在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

botF Antibody, Biotin conjugated

Rare Species
  • 中文名稱:
    botF兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA341192HD01CLQ
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Clostridium botulinum botF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    botF
  • 別名:
    botFBotulinum neurotoxin type F antibody; BoNT/F antibody; Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin F heavy chain antibody; HC)] antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Clostridium botulinum
  • 免疫原:
    Recombinant Clostridium botulinum Botulinum neurotoxin type F protein (1-436AA)
  • 免疫原種屬:
    Clostridium botulinum
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. Whole toxin only has protease activity after reduction, which releases LC. Requires complex eukaryotic host polysialogangliosides for full neurotoxicity. It is not clear whether a synaptic vesicle protein acts as its receptor; there is evidence for and against SV2 fulfilling this function.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '60-Gln-|-Lys-61' bond of synaptobrevin-1/VAMP1 and the equivalent 'Gln-|-Lys' sites in VAMP2 and VAMP3. Cleaves the '48-Gln-|-Lys-49' bond of A.californica synaptobrevin (AC P35589).; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The RBD is responsible for the adherence of the toxin to the cell surface. It simultaneously recognizes 2 coreceptors; polysialated gangliosides and the receptor protein SV2A, SV2B and SV2C in close proximity on host synaptic vesicles; although not all evidence indicates these are the receptors. The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol.
  • 亞細(xì)胞定位:
    [Botulinum neurotoxin type F]: Secreted.; [Botulinum neurotoxin F light chain]: Secreted. Host cytoplasm, host cytosol.; [Botulinum neurotoxin F heavy chain]: Secreted. Host cell junction, host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 伊人久久大香线蕉影院| 日本一区二区三区免费更新不卡 | 亚洲a∨国产av综合av下载| 亚洲妇女无套内射精| 国产熟女一区二区三区四区五区 | 中文字幕无码免费久久| 亚洲精品国产精品国自产| 香蕉免费一区二区三区| 日韩精品人妻无码久久影院| 国产精品久久久久久爽爽爽床戏| 亚洲狠狠做深爱婷婷影院| 久久人妻av中文字幕| 久久亚洲国产精品成人av秋霞 | 电影久久久久久| 成人爽a毛片在线视频| 久久www免费人成一看片 | 鲁大师影院在线观看| 中文字幕乱码一区av久久| 亚洲国产成人精品无码区二本| 亚洲男人天堂| 午夜射精日本三级| 国产无套护士在线观看| 日本无码一区二区三区不卡免费| 337p日本欧洲亚洲大胆裸体艺术| 青草视频在线播放| 亚洲日韩穿丝袜在线推荐| 国产制服丝袜欧美在线观看| 国产一性一交一伦一a片| 国产精品久久久久av| 国产av影片麻豆精品传媒| 久久av无码精品人妻系列试探| 国产色在线 | 亚洲| 久久中文精品无码中文字幕| 亚洲最大成人网 色香蕉| 久久久国产精品无码免费专区| 香港三级韩国三级日本三级| 99九九99九九视频精品| 亚洲国产欧美在线人成app| 瑜伽裤国产一区二区三区| 久久不见久久见免费视频6无删减| 欧美成人午夜免费影院手机在线看|