在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bacillus anthracis Protective antigen (pagA), partial

Recombinant Bacillus anthracis Protective antigen (pagA), partial

  • 中文名稱：
    炭疽桿菌pagA重組蛋白
  • 貨號：
    CSB-YP320223BQE(A4)
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    炭疽桿菌pagA重組蛋白
  • 貨號：
    CSB-EP320223BQE(A4)
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    炭疽桿菌pagA重組蛋白
  • 貨號：
    CSB-EP320223BQE(A4)-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    炭疽桿菌pagA重組蛋白
  • 貨號：
    CSB-BP320223BQE(A4)
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    炭疽桿菌pagA重組蛋白
  • 貨號：
    CSB-MP320223BQE(A4)
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    pagA
  • Uniprot No.：
  • 別名：
    pagA; pag; pXO1-110; BXA0164; GBAA_pXO1_0164Protective antigen; PA; Anthrax toxins translocating protein; PA-83; PA83) [Cleaved into: Protective antigen PA-20; PA20); Protective antigen PA-63; PA63)]
  • 種屬：
    Bacillus anthracis
  • 蛋白長度：
    Partial
  • 表達區域：
    30-196
  • 氨基酸序列
    EVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYF QSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQY QRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax.; Mediates the attachment to host cells by binding host cell receptors ANTXR1 and ANTXR2. Following host cell surface attachment, PA is cleaved by FURIN to generate the PA-63 (Protective antigen PA-63) form, which constitutes the mature form of the protein that oligomerizes and forms a pore to translocate the enzymatic toxin components edema factor (EF) and lethal factor (LF) into the host cytosol.; Mature form that oligomerizes and forms a pore to translocate the enzymatic toxin components edema factor (EF) and lethal factor (LF) into the host cytosol. Following attachment to host cell receptors and cleavage by FURIN, homooligomerizes to form ring-shaped oligomers that are in a pre-pore conformation, and associates with EF and LF. Toxin-leaded complexes are then endocytosed in a clathrin-dependent process, followed by a conformational change of oligomerized PA-63 from the pre-pore to pore state, which is triggered by the low pH in the endosome. Once active, the pore mediates unfolding of EF and LF, which pass through the pore and translocate into the host cytosol.
  • 基因功能參考文獻：
    1. PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. PMID: 30052476
    2. Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability PMID: 27874231
    3. Data show that both mutant and native protective antigen vaccine preparations protected rabbits from lethal, aerosolized, spore challenge. PMID: 26207820
    4. Data suggest that anthrax protective antigen (PA) expressing Semliki Forest virus (SFV) replicon DNA or viral replicon particles (VRP) vaccines may be suitable as candidate vaccines against anthrax. PMID: 25102364
    5. N435C mutantion of anthrax protective antigen conferred dominant-negative inhibitory activity. PMID: 20213183
    6. analysis of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies PMID: 19617628

    顯示更多

    收起更多

  • 亞細胞定位：
    [Protective antigen]: Secreted. Host cell membrane.; [Protective antigen PA-63]: Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bacterial binary toxin family
  • 數據庫鏈接：


主站蜘蛛池模板： 男女猛烈无遮挡免费视频在线观看 | 亚洲国产av精品一区二区蜜芽| 亚洲国产无线乱码在线观看| 亚洲欧美日本国产专区一区| 美女粉嫩饱满的一线天mp4| 西西人体做爰大胆性自慰| 欧美牲交a欧美牲交aⅴ久久| 亚洲国产综合精品 在线 一区| 国产清纯美女爆白浆视频| 女人被爽到高潮视频免费国产| 精品国偷自产在线| 情欲少妇人妻100篇| 亚洲444kkkk在线观看| 狠狠色噜噜狠狠狠888米奇| 色欲色香天天天综合无码www| 国产欧美va欧美va香蕉在线观看| 野外被强j到高潮免费观看| 亚洲а∨精品天堂在线| 国产欧美日韩精品a在线观看| 国产成人一区二区精品视频 | 男女下面进入的视频免费午夜| 精品久久久久久无码专区不卡| 国产成人亚洲精品另类动态| 小污女导航福利入口| 国产av熟女一区二区三区| 乱中年女人伦av| 久久久久久国产精品无码超碰| 天堂官网在线资源网| 最美女人体内射精一区二区| 18禁止看的免费污网站| 国产在线拍偷自揄拍无码| 久久激情综合狠狠爱五月| 亚洲人成人77777网站| 久久亚洲私人国产精品| 四虎国产精品一区二区| 免费国产高清在线精品一区| 无码中文字幕日韩专区视频| 无码国产精品免费看| 国产精品区一区二区三在线播放| 免费无码精品黄av电影| 99久久精品精品6精品精品|