在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bacillus anthracis Protective antigen (pagA), partial

  • 中文名稱:
    炭疽桿菌pagA重組蛋白
  • 貨號:
    CSB-YP320223BQE
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    炭疽桿菌pagA重組蛋白
  • 貨號:
    CSB-EP320223BQE
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    炭疽桿菌pagA重組蛋白
  • 貨號:
    CSB-EP320223BQE-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    炭疽桿菌pagA重組蛋白
  • 貨號:
    CSB-BP320223BQE
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    炭疽桿菌pagA重組蛋白
  • 貨號:
    CSB-MP320223BQE
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    pagA
  • Uniprot No.:
  • 別名:
    pagA; pag; pXO1-110; BXA0164; GBAA_pXO1_0164Protective antigen; PA; Anthrax toxins translocating protein; PA-83; PA83) [Cleaved into: Protective antigen PA-20; PA20); Protective antigen PA-63; PA63)]
  • 種屬:
    Bacillus anthracis
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax.; Mediates the attachment to host cells by binding host cell receptors ANTXR1 and ANTXR2. Following host cell surface attachment, PA is cleaved by FURIN to generate the PA-63 (Protective antigen PA-63) form, which constitutes the mature form of the protein that oligomerizes and forms a pore to translocate the enzymatic toxin components edema factor (EF) and lethal factor (LF) into the host cytosol.; Mature form that oligomerizes and forms a pore to translocate the enzymatic toxin components edema factor (EF) and lethal factor (LF) into the host cytosol. Following attachment to host cell receptors and cleavage by FURIN, homooligomerizes to form ring-shaped oligomers that are in a pre-pore conformation, and associates with EF and LF. Toxin-leaded complexes are then endocytosed in a clathrin-dependent process, followed by a conformational change of oligomerized PA-63 from the pre-pore to pore state, which is triggered by the low pH in the endosome. Once active, the pore mediates unfolding of EF and LF, which pass through the pore and translocate into the host cytosol.
  • 基因功能參考文獻(xiàn):
    1. PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. PMID: 30052476
    2. Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability PMID: 27874231
    3. Data show that both mutant and native protective antigen vaccine preparations protected rabbits from lethal, aerosolized, spore challenge. PMID: 26207820
    4. Data suggest that anthrax protective antigen (PA) expressing Semliki Forest virus (SFV) replicon DNA or viral replicon particles (VRP) vaccines may be suitable as candidate vaccines against anthrax. PMID: 25102364
    5. N435C mutantion of anthrax protective antigen conferred dominant-negative inhibitory activity. PMID: 20213183
    6. analysis of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies PMID: 19617628

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Protective antigen]: Secreted. Host cell membrane.; [Protective antigen PA-63]: Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Bacterial binary toxin family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 综合无码一区二区三区| 精品一区二区三区在线播放视频| 少妇被又大又粗又爽毛片久久黑人| 久久只精品99品免费久23| 人妻体验按摩到忍不住哀求继续| 久久99精品久久久大学生| 免费无码av一区二区| 久久综合少妇11p| 50岁熟妇的呻吟声对白| 最新国产av无码专区亚洲| 中文字幕亚洲无线码在线一区| 少妇特殊按摩高潮惨叫无码| 97人妻免费碰视频碰免| 好了av第四综合无码久久| 国产精品理论片| 久久97国产超碰青草| 日韩欧国产精品一区综合无码| 久久99精品国产免费观观| 成人h动漫精品一区二区无码| 欧妇女乱妇女乱视频| 国产av成人精品播放| 2019久久久最新精品| 日韩av午夜在线观看| 国产无套内射又大又猛又粗又爽| 18禁男女污污污午夜网站免费暖暖| 2019最新中文字幕在线观看| 无码人妻av一区二区三区蜜臀| 欧洲精品欧美精品| 色哟哟免费视频播放网站| 日本中文字幕亚洲乱码| 精品亚洲一区二区三区四区五区| 日韩精品一区国产偷窥在线| 亚洲综合久久成人a片| 欧美人妻日韩精品| 亚洲 欧美 成人 自拍 高清| 欧美日韩人妻精品一区二区在线| 精产国品一二三产品蜜桃| 久久精品动漫一区二区三区| 国产线观看免费观看| 色婷婷av一区二区三区浪潮| 45分钟免费真人视频|