在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. PRKAG1 Recombinant Monoclonal Antibody

PRKAG1 Recombinant Monoclonal Antibody

  • 中文名稱：
    PRKAG1重組抗體
  • 貨號：
    CSB-RA161743A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA161743A0HU diluted at 1:100 and staining in paraffin-embedded human Prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA161743A0HU PRKAG1重組單克隆抗體是針對AMP激活蛋白激酶γ1亞基（PRKAG1）研發的高特異性科研工具。該抗體靶向的PRKAG1作為AMPK復合物的關鍵調控組分，在細胞能量代謝平衡、糖脂代謝調控及應激響應中發揮核心作用，其功能異常與代謝性疾病及心血管疾病的發生發展密切相關。本產品經嚴格驗證，在ELISA和免疫組化（IHC）實驗中展現優異性能，特別適用于石蠟包埋組織樣本的檢測，推薦使用稀釋比例為1:50-1:200時可獲得清晰的特異性信號。該抗體適用于探究能量代謝相關信號通路機制、疾病模型中的蛋白表達定位研究，以及代謝綜合征、心肌肥厚等病理過程的分子機制解析，為細胞代謝調控、疾病生物標志物篩選等基礎研究領域提供可靠檢測方案。
  • Uniprot No.：
  • 基因名：
  • 別名：
    5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg), PRKAG1
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PRKAG1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    5E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
  • 基因功能參考文獻：
    1. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
    2. Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK PMID: 26276391
    3. Letter: report PRKAG1 frameshift mutations in colorectal cancer. PMID: 25267969
    4. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). PMID: 24356547
    5. PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. PMID: 23479427
    6. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. PMID: 22456184
    7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. PMID: 19052260

    顯示更多

    收起更多

  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 數據庫鏈接：

    HGNC: 9385

    OMIM: 602742

    KEGG: hsa:5571

    STRING: 9606.ENSP00000323867

    UniGene: Hs.530862



主站蜘蛛池模板： 久久只精品99品免费久23| 亚洲自偷自偷在线成人网址| 亚洲国产精品综合久久网各| 国产免费麻传媒精品国产av| 国产在线不卡人成视频| 国产曰批免费视频播放免费| 亚洲精品久久久久中文字幕| 亚洲日韩乱码一区二区三区四区| 在线天堂中文www官网| 成年女人永久免费看片| 久久99精品久久久久久蜜芽| 国产精品久久久久久久久绿色 | 国产麻豆剧传媒精品国产av| 成品人视频ww入口| 疯狂做受xxxx高潮欧美日本| 国产重口老太和小伙乱| 国产av巨作丝袜秘书| 无尺码精品产品网站| 婷婷亚洲久悠悠色悠在线播放| 人妻洗澡被强公日日澡电影| 亚洲龙腾成小说人网| 亚洲无碼网站观看| 午夜视频在线瓜伦| 水蜜桃av无码| 国产福利萌白酱精品tv一区| 亚洲中文字幕日产无码2020| 久久国产精品无码一区二区三区 | 亚洲综合色在线观看一区| 强奷妇系列中文字幕| 亚洲中文字幕无码中文字| 人妻少妇69式99偷拍| 亚洲 欧美 天堂 综合| 国语精品自产拍在线观看网站 | 国产suv精品一区| 国产真实野战在线视频| 午夜福利午夜福利1000| 国产在线不卡精品网站| 无码人妻精品一区二区三区9厂| 国产精品久久久久久久妇| 国产精品视频观看裸模| 熟妇高潮一区二区三区|