在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PRKAG1 Antibody

PRKAG1 Antibody

  • 中文名稱：
    PRKAG1兔多克隆抗體
  • 貨號：
    CSB-PA086142
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells and 293 cells, using PRKAG1/2/3 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PRKAG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human PRKAG1/2/3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
    2. Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK PMID: 26276391
    3. Letter: report PRKAG1 frameshift mutations in colorectal cancer. PMID: 25267969
    4. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). PMID: 24356547
    5. PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. PMID: 23479427
    6. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. PMID: 22456184
    7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. PMID: 19052260

    顯示更多

    收起更多

  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9385

    OMIM: 602742

    KEGG: hsa:5571

    STRING: 9606.ENSP00000323867

    UniGene: Hs.530862



主站蜘蛛池模板： 久久久无码一区二区三区| 正在播放国产剧情亂倫| 国产成人无码aa精品一区| 国模叶桐尿喷337p人体| 好了av四色综合无码久久| 日韩免费一区二区三区高清| 欧美肥老太交性506070| 亚洲日韩中文字幕无码一区| 无码午夜成人1000部免费视频| 日本一区二区无卡高清视频| 午夜少妇性影院私人影院在线| 免费久久99精品国产自在现线| 777米奇影视第四色| 国偷自产一区二区三区在线视频| 日韩少妇人妻vs中文字幕| 午夜精品一区二区三区的区别| 无码免费午夜福利看片| 国产精品嫩草99av在线| 一本久道中文无码字幕av| 久久国产精品-国产精品| 亚洲精品一品区二品区三区| 国产99视频精品免费观看9| 免费看欧美成人a片无码| 色翁荡息又大又硬又粗又爽| 亚洲精品国产自在现线看| 亚洲精品久久久www小说 | 欧美又大粗又爽又黄大片视频| 四虎一区二区成人免费影院网址| 乱子伦国产对白在线播放| 粉色午夜视频| 无码av天堂一区二区三区| 天堂av无码大芭蕉伊人av不卡| 国产精华av午夜在线| 天堂中文最新版在线官网在线 | 欧美xxxx做受欧美69| 免费午夜男女高清视频| 亚洲综合一区二区三区无码| 亚洲中文字幕无码人在线| 久久99久久99久久综合| 少妇被躁爽到高潮无码久久| 高清情侣国语自产拍|