在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. NEFM Recombinant Monoclonal Antibody

NEFM Recombinant Monoclonal Antibody

  • 中文名稱：
    NEFM Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA054260A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate(30μg), HEK293T whole cell lysate(30μg)
      All lanes: NEFM antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 102 kDa
      Observed band size: 160 kDa
      Exposure time：3min
    • IHC image of CSB-RA054260A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NEFM
  • 別名：
    Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein), NEFM, NEF3 NFM
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human NEFM protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6F12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
  • 基因功能參考文獻：
    1. Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. PMID: 28634551
    2. NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R internalization from the plasma membrane in Adosterone-producing Adenomas. PMID: 28584012
    3. There was a strongly elevated reactivity against neurofilament medium in a subset of schizophrenia patients compared to controls. PMID: 24636402
    4. direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease PMID: 20624930
    5. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
    6. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
    7. To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L. PMID: 12133495
    8. Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients. PMID: 14583397
    9. The G336S variant of hNF-M does not affect the formation of IF networks nor the distribution of the variant hNFM protein. If the G336S variant is involved in the development of PD, it isn't due to defects in the assembly and distribution of NFs. PMID: 15290901
    10. O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role. PMID: 16006557
    11. mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in amytrophic lateral sclerosis in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes PMID: 16084104
    12. variation in NEF3 influence rate of response to typical antipsychotic medication PMID: 16734940

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, axon.
  • 蛋白家族：
    Intermediate filament family
  • 數據庫鏈接：

    HGNC: 7734

    OMIM: 162250

    KEGG: hsa:4741

    STRING: 9606.ENSP00000221166

    UniGene: Hs.458657



主站蜘蛛池模板： 国产三级在线观看完整版| 免费又黄又爽又猛的毛片| 亚洲国产精品无码中文字2022| 欧美疯狂做受xxxx高潮| 黄页网站视频| 真实国产乱子伦精品一区二区三区| 女性自慰网站免费看ww| 成人黄网站高清免费视频| 无码熟妇人妻av在线电影| 小蜜被两老头吸奶头在线观看| 免费观看女人高潮视频软件| 国产肉丝袜视频在线观看| 日本中文字幕亚洲乱码| 精品 日韩 国产 欧美 视频 | 成人午夜高潮刺激免费视频| 国产亚洲精品一区二三区| 天天摸夜夜添夜夜无码| 青娱乐极品视觉盛宴国产视频| 久久综合色一综合色88| 最新在线精品国自产拍视频| 国产人久久人人人人爽| 国产精久久一区二区三区| 欧美色偷偷亚洲天堂bt| 国产精品午夜小视频观看| 成年免费视频黄网站zxgk| 人与狗精品aa毛片| 亚洲一二区制服无码中字| 99久热re在线精品99re8热视频| 国产乱码人妻一区二区三区四区| 在教室伦流澡到高潮hgl动漫| 亚洲国产精品隔壁老王| 一个人看的www免费视频在线观看 亚洲国产成人久久一区www | aa片在线观看视频在线播放| 极品无码av国模在线观看| 麻豆精品传媒一二三区艾秋| 狠狠色婷婷久久一区二区三区| 亚洲小说图区综合在线| 无码熟妇人妻av在线网站| 久久精品国产精品亚洲艾草网| 亚洲成av人在线播放无码| 久热这里只精品99国产6-99re视…|