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  4. NEFM Antibody

NEFM Antibody

  • 中文名稱：
    NEFM兔多克隆抗體
  • 貨號：
    CSB-PA020050
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NEFM
  • 別名：
    150kDa medium antibody; 160 kDa neurofilament protein antibody; 2 kDa neurofilament protein antibody; 200 kDa neurofilament protein antibody; 68 kDa neurofilament protein antibody; AI847934 antibody; CMT1F antibody; CMT2CC antibody; CMT2E antibody; FLJ53642 antibody; KIAA0845 antibody; light molecular weight neurofilament protein antibody; Micro glutamic acid-rich protein antibody; mKIAA0845 antibody; Nef3 antibody; NEFH antibody; NEFL antibody; NEFM antibody; Neurofilament 3 antibody; Neurofilament heavy polypeptide 200kDa antibody; Neurofilament heavy polypeptide antibody; Neurofilament light polypeptide 68kDa antibody; Neurofilament light polypeptide antibody; Neurofilament medium polypeptide 150kDa antibody; Neurofilament medium polypeptide antibody; Neurofilament protein heavy polypeptide antibody; Neurofilament protein light chain antibody; Neurofilament protein light polypeptide antibody; Neurofilament protein medium polypeptide antibody; neurofilament subunit NF-L antibody; Neurofilament triplet H protein antibody; Neurofilament triplet L protein antibody; Neurofilament triplet M protein antibody; neurofilament-3 (150 kD medium) antibody; NF-H antibody; NF-L antibody; NF-M antibody; NF160 antibody; NF165 antibody; NF200 antibody; NF68 antibody; NFH antibody; NFL antibody; NFM antibody; NFM_HUMAN antibody; PPP1R110 antibody; protein phosphatase 1, regulatory subunit 110 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NF-M.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
  • 基因功能參考文獻：
    1. Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. PMID: 28634551
    2. NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R internalization from the plasma membrane in Adosterone-producing Adenomas. PMID: 28584012
    3. There was a strongly elevated reactivity against neurofilament medium in a subset of schizophrenia patients compared to controls. PMID: 24636402
    4. direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease PMID: 20624930
    5. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
    6. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
    7. To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L. PMID: 12133495
    8. Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients. PMID: 14583397
    9. The G336S variant of hNF-M does not affect the formation of IF networks nor the distribution of the variant hNFM protein. If the G336S variant is involved in the development of PD, it isn't due to defects in the assembly and distribution of NFs. PMID: 15290901
    10. O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role. PMID: 16006557
    11. mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in amytrophic lateral sclerosis in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes PMID: 16084104
    12. variation in NEF3 influence rate of response to typical antipsychotic medication PMID: 16734940

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, axon.
  • 蛋白家族：
    Intermediate filament family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7734

    OMIM: 162250

    KEGG: hsa:4741

    STRING: 9606.ENSP00000221166

    UniGene: Hs.458657



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