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LEFTY2 Recombinant Monoclonal Antibody

  • 中文名稱：
    LEFTY2重組抗體
  • 貨號：
    CSB-RA171603A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate
      All lanes: LEFTY2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 38 kDa
      Observed band size: 36-45 kDa
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA171603A0HU LEFTY2 Recombinant Monoclonal Antibody是針對發育調控關鍵因子LEFTY2設計的高特異性檢測工具。該抗體靶向的LEFTY2蛋白屬于TGF-β超家族成員，在胚胎左右軸模式形成、組織器官發育及細胞命運決定中發揮重要作用，同時參與腫瘤微環境調控等病理過程。經嚴格驗證，本重組單克隆抗體在Western Blot（WB）實驗中表現出優異的靶標識別能力，推薦使用稀釋比為1:500-1:2000時能清晰檢測目標蛋白表達，同時在ELISA平臺也具備可靠檢測性能，適用于多種哺乳動物細胞裂解液或組織樣本的分析。研究人員可利用該抗體探索胚胎發育異常機制、干細胞分化調控以及腫瘤發生發展過程中LEFTY2介導的信號通路，特別是在研究器官不對稱發育、癌癥細胞侵襲轉移抑制、以及TGF-β超家族配體互作網絡等領域具有重要應用價值。該產品采用重組表達技術保證批次穩定性，為發育生物學、腫瘤學及細胞信號轉導研究提供高質量的實驗保障。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4), LEFTY2, EBAF LEFTA LEFTYA TGFB4
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human LEFTY2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10G2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • 基因功能參考文獻：
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
    3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
    4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
    5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
    6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
    9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
    12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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  • 相關疾病：
    Left-right axis malformations (LRAM)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Mesenchymal cells of the endometrial stroma.
  • 數據庫鏈接：

    HGNC: 3122

    OMIM: 601877

    KEGG: hsa:7044

    STRING: 9606.ENSP00000355785

    UniGene: Hs.520187



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