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LEFTY2 Antibody

  • 中文名稱:
    LEFTY2兔多克隆抗體
  • 貨號:
    CSB-PA991744
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA991744(LEFTY2 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    EBAF antibody; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody; Endometrial bleeding associated factor antibody; Endometrial bleeding-associated factor antibody; Left right determination factor 2 antibody; Left right determination factor A antibody; Left-right determination factor 2 antibody; Left-right determination factor A antibody; LEFTA antibody; LEFTY 2 antibody; LEFTY2 antibody; LEFTYA antibody; LFTY2 transforming growth factor; beta -4 antibody; LFTY2; mouse; homolog of antibody; LFTY2_HUMAN antibody; MGC46222 antibody; Protein lefty 2 antibody; Protein lefty A antibody; Protein lefty-2 antibody; Protein lefty-A antibody; Protein lefty2 antibody; PSEC0024 antibody; TGF beta 4 antibody; TGF-beta-4 antibody; TGFB4 antibody; Transforming growth factor beta 4 antibody; Transforming growth factor beta-4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Full length fusion protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • 基因功能參考文獻(xiàn):
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
    3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
    4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
    5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
    6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
    9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
    12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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  • 相關(guān)疾病:
    Left-right axis malformations (LRAM)
  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family
  • 組織特異性:
    Mesenchymal cells of the endometrial stroma.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3122

    OMIM: 601877

    KEGG: hsa:7044

    STRING: 9606.ENSP00000355785

    UniGene: Hs.520187



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