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  4. CEACAM8 Recombinant Monoclonal Antibody

CEACAM8 Recombinant Monoclonal Antibody

  • 中文名稱：
    CEACAM8重組抗體
  • 貨號：
    CSB-RA005168MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CEACAM8 with Anti-CEACAM8 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM8 (CSB-MP005168HU) at 2 μg/mL can bind Anti-CEACAM8 recombinant antibody, the EC50 is 19.38-21.68 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA005168MA1HU 是靶向人源 CEACAM8 蛋白的重組單克隆抗體，采用小鼠雜交瘤技術(shù)制備，具有高親和力與批次穩(wěn)定性。CEACAM8 屬于癌胚抗原相關(guān)細胞黏附分子家族（CEACAM），主要在中性粒細胞表面表達，參與炎癥反應(yīng)調(diào)控及病原體識別，其異常表達與慢性炎癥性疾病、感染性疾病及免疫調(diào)節(jié)研究相關(guān)。本抗體經(jīng) ELISA 驗證可特異性識別天然及重組 CEACAM8 蛋白，適用于體外樣本中靶蛋白的定性或半定量檢測。應(yīng)用場景涵蓋炎癥機制研究、免疫細胞功能分析以及相關(guān)信號通路探索，可為體外細胞模型、蛋白互作研究或免疫組化實驗提供可靠工具，助力科研人員解析 CEACAM8 在免疫應(yīng)答中的分子作用。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Carcinoembryonic antigen CGM6 antibody; Carcinoembryonic antigen gene family member 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 8 antibody; Carcinoembryonic antigen-related cell adhesion molecule 8 antibody; CD 66b antibody; CD 67 antibody; CD66b antibody; CD66b antigen antibody; CD67 antibody; CD67 antigen antibody; CEACAM 8 antibody; CEACAM8 antibody; CEAM8_HUMAN antibody; CGM 6 antibody; CGM6 antibody; NCA 95 antibody; NCA95 antibody; Non-specific cross-reacting antigen NCA-95 antibody; Nonspecific cross reacting antigen NCA 95 antibody; Nonspecific cross reacting antigen NCA95 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CEACAM8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22H9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能參考文獻：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 組織特異性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41



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