在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. CAPNS1 Recombinant Monoclonal Antibody

CAPNS1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CAPNS1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA947028A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate(30μg), A431 whole cell lysate(30μg), PC-3 whole cell lysate(30μg), HeLa whole cell lysate(30μg), U-251MG whole cell lysate(30μg), THP-1 whole cell lysate(30μg)
      All lanes: CAPNS1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 28 kDa
      Observed band size: 28 kDa
      Exposure time：2min
    • Immunofluorescence staining of A549 cell with CSB-RA947028A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing Hela cells stained with CSB-RA947028A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CAPNS1
  • 別名：
    Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit), CAPNS1, CAPN4 CAPNS
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human CAPNS1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9G3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 基因功能參考文獻：
    1. that Capn4 promotes cell proliferation by increasing MAPK7 expression PMID: 29331389
    2. Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. PMID: 29648579
    3. Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. PMID: 29331762
    4. MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. PMID: 28857668
    5. Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. PMID: 27878263
    6. CAPNS1 depletion is coupled to impairment of breast cancer cell growth. PMID: 26771715
    7. High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. PMID: 25636510
    8. HBXIP was able to up-regulate Capn4 at the levels of promoter. PMID: 25304384
    9. The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706
    10. Capn4 can contribute to hepatocellular carcinoma growth and metastasis PMID: 24962955
    11. Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. PMID: 24514433
    12. Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB. PMID: 24703594
    13. This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. PMID: 24297866
    14. Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma PMID: 23349941
    15. The authors conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells. PMID: 20419804
    16. CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress PMID: 20107320
    17. Genetic variations in LEP, CAPNS1 and ALOX15 show significant association with IL-6 expression. PMID: 19942621
    18. calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. PMID: 12121983
    19. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    20. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    21. c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells PMID: 18544539
    22. RasGAP and Capns1 interaction in oncogenic Ras cells is involved in regulating migration and cell survival. PMID: 18761085

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell membrane.
  • 數據庫鏈接：

    HGNC: 1481

    OMIM: 114170

    KEGG: hsa:826

    STRING: 9606.ENSP00000246533

    UniGene: Hs.515371



主站蜘蛛池模板： 国产成人av乱码免费观看| 亚洲aⅴ综合色区无码一区| 国产情侣大量精品视频| 日本熟妇色xxxxx欧美老妇| 人妻av中文字幕无码专区| 人妻丰满熟妞av无码区| 亚洲久热中文字幕在线| 午夜福利视频一区二区手机免费看| 亚洲精品久久夜色撩人男男小说| 毛片免费视频肛交颜射免费视频 | 国产又色又爽又刺激视频| 人人做人人爽久久久精品| 日韩欧美mv在线观看免费| 亚洲电影在线观看| 综合图片亚洲综合网站| 亚洲性人人天天夜夜摸18禁止| 18禁午夜宅男成年网站| 日韩精品一区二区在线观看| 国产乱人伦偷精品视频免观看 | xx性欧美肥妇精品久久久久久| 最新国产精品自在线观看| 美女扒开腿让男人桶爽揉| 亚洲精品午夜国产va久久成人| 乱码av麻豆丝袜熟女系列| 婷婷丁香五月六月综合激情啪| 麻花豆传媒剧国产免费mv观看| 久久伊人蜜桃av一区二区| 国产大屁股视频免费区| 亚洲超清无码制服丝袜无广告| 男女18禁啪啪无遮挡| 色欲人妻aaaaaaa无码| 天天做av天天爱天天爽| 欧美精品人人做人人爱视频| 日韩av无码精品人妻系列| 亚洲综合av色婷婷| 性色av一区二区三区人妻| 四虎成人精品在永久免费| 久久久一本精品99久久精品66| 人人澡人人澡人人看添av| 久久久国产精品无码免费专区 | 无码 制服 丝袜 国产 另类|