在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CAPNS1 Antibody

  • 中文名稱:
    CAPNS1兔多克隆抗體
  • 貨號:
    CSB-PA921513
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA921513(CAPNS1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 60 μg, Lane 1-3: Mouse spleen tissue, K562 cells, NIH/3T3 cells, Primary antibody: CSB-PA921513(CAPNS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CAPNS1
  • 別名:
    30K antibody; Calcium activated neutral proteinase antibody; Calcium activated neutral proteinase small subunit antibody; Calcium dependent protease small subunit 1 antibody; Calcium dependent protease small subunit antibody; Calcium-activated neutral proteinase small subunit antibody; Calcium-dependent protease small subunit 1 antibody; Calcium-dependent protease small subunit antibody; Calpain 4 antibody; Calpain 4 small subunit (30K) antibody; Calpain 4 small subunit antibody; Calpain regulatory subunit antibody; Calpain S1 antibody; Calpain small polypeptide antibody; Calpain small subunit 1 antibody; Calpain4 antibody; CalpainS1 antibody; CANP antibody; CANP small subunit antibody; CANPS antibody; CAPN 4 antibody; CAPN S1 antibody; CAPN4 antibody; CAPNS 1 antibody; CAPNS antibody; Capns1 antibody; CDPS antibody; CPNS1_HUMAN antibody; CSS 1 antibody; CSS1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human CAPNS1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 基因功能參考文獻:
    1. that Capn4 promotes cell proliferation by increasing MAPK7 expression PMID: 29331389
    2. Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. PMID: 29648579
    3. Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. PMID: 29331762
    4. MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. PMID: 28857668
    5. Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. PMID: 27878263
    6. CAPNS1 depletion is coupled to impairment of breast cancer cell growth. PMID: 26771715
    7. High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. PMID: 25636510
    8. HBXIP was able to up-regulate Capn4 at the levels of promoter. PMID: 25304384
    9. The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706
    10. Capn4 can contribute to hepatocellular carcinoma growth and metastasis PMID: 24962955
    11. Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. PMID: 24514433
    12. Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB. PMID: 24703594
    13. This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. PMID: 24297866
    14. Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma PMID: 23349941
    15. The authors conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells. PMID: 20419804
    16. CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress PMID: 20107320
    17. Genetic variations in LEP, CAPNS1 and ALOX15 show significant association with IL-6 expression. PMID: 19942621
    18. calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. PMID: 12121983
    19. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    20. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    21. c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells PMID: 18544539
    22. RasGAP and Capns1 interaction in oncogenic Ras cells is involved in regulating migration and cell survival. PMID: 18761085

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 數據庫鏈接:

    HGNC: 1481

    OMIM: 114170

    KEGG: hsa:826

    STRING: 9606.ENSP00000246533

    UniGene: Hs.515371



主站蜘蛛池模板: 国产传媒精品1区2区3区| 免费观看成人毛片a片| 苍井空一区二区波多野结衣av| 精品少妇无码av无码专区| 人人澡超碰碰97碰碰碰| 亚洲天堂2017无码| 色欲天天婬色婬香综合网完整版 | 国产精品亚洲а∨天堂网| 色综久久综合桃花网国产精品| 韩国国内大量揄拍精品视频| 好男人在线社区www在线影院| 公么大龟弄得我好舒服秀婷视频| 精品国产18久久久久久| 精品久久久久久无码国产| 亚洲a∨国产av综合av网站| 护士av无码在线观看| 欧美变态口味重另类在线视频 | 免费精品国产人妻国语| 欧美黑人粗大xxxxbbbb| 亚洲中文字幕av不卡无码| 亚洲国内成人精品网| 宅男噜噜噜66网站在线观看| 久久人人爽人人爽人人片av麻烦| 亚洲熟妇久久国内精品| 日本护士xxxxhd少妇| 自拍偷在线精品自拍偷免费| 国产av一区二区三区日韩| 人人妻人人澡人人爽国产一区 | 国产成人精品无码专区| 国产精品成人永久在线四虎| 亚洲成av人片天堂网久久| 久久精品青青草原伊人| 凹凸在线无码免费视频| 香蕉午夜福利院| 亚洲精品无码人妻无码| 免费无码黄十八禁网站在线观看| 国产性天天综合网| 亚洲精品国产一区二区| 国产精品久久综合免费| 国产台湾无码av片在线观看 | 欧美性白人极品hd|