在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CAPNS1 Antibody

  • 中文名稱:
    CAPNS1兔多克隆抗體
  • 貨號:
    CSB-PA921513
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA921513(CAPNS1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 60 μg, Lane 1-3: Mouse spleen tissue, K562 cells, NIH/3T3 cells, Primary antibody: CSB-PA921513(CAPNS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CAPNS1
  • 別名:
    30K antibody; Calcium activated neutral proteinase antibody; Calcium activated neutral proteinase small subunit antibody; Calcium dependent protease small subunit 1 antibody; Calcium dependent protease small subunit antibody; Calcium-activated neutral proteinase small subunit antibody; Calcium-dependent protease small subunit 1 antibody; Calcium-dependent protease small subunit antibody; Calpain 4 antibody; Calpain 4 small subunit (30K) antibody; Calpain 4 small subunit antibody; Calpain regulatory subunit antibody; Calpain S1 antibody; Calpain small polypeptide antibody; Calpain small subunit 1 antibody; Calpain4 antibody; CalpainS1 antibody; CANP antibody; CANP small subunit antibody; CANPS antibody; CAPN 4 antibody; CAPN S1 antibody; CAPN4 antibody; CAPNS 1 antibody; CAPNS antibody; Capns1 antibody; CDPS antibody; CPNS1_HUMAN antibody; CSS 1 antibody; CSS1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human CAPNS1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 基因功能參考文獻:
    1. that Capn4 promotes cell proliferation by increasing MAPK7 expression PMID: 29331389
    2. Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. PMID: 29648579
    3. Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. PMID: 29331762
    4. MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. PMID: 28857668
    5. Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. PMID: 27878263
    6. CAPNS1 depletion is coupled to impairment of breast cancer cell growth. PMID: 26771715
    7. High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. PMID: 25636510
    8. HBXIP was able to up-regulate Capn4 at the levels of promoter. PMID: 25304384
    9. The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706
    10. Capn4 can contribute to hepatocellular carcinoma growth and metastasis PMID: 24962955
    11. Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. PMID: 24514433
    12. Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB. PMID: 24703594
    13. This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. PMID: 24297866
    14. Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma PMID: 23349941
    15. The authors conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells. PMID: 20419804
    16. CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress PMID: 20107320
    17. Genetic variations in LEP, CAPNS1 and ALOX15 show significant association with IL-6 expression. PMID: 19942621
    18. calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. PMID: 12121983
    19. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    20. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    21. c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells PMID: 18544539
    22. RasGAP and Capns1 interaction in oncogenic Ras cells is involved in regulating migration and cell survival. PMID: 18761085

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 數據庫鏈接:

    HGNC: 1481

    OMIM: 114170

    KEGG: hsa:826

    STRING: 9606.ENSP00000246533

    UniGene: Hs.515371



主站蜘蛛池模板: 影音先锋中文无码一区| 精品乱码久久久久久中文字幕| 精品玖玖玖视频在线观看| 亚洲日韩乱码中文字幕| 国产麻豆精品福利在线| 色99久久久久高潮综合影院| 人妻去按摩店被黑人按中出| 天天躁日日躁狠狠很躁| 国产va免费精品高清在线| 亚洲成av人无码中文字幕| 亚洲人精品亚洲人成在线| 亚洲国产区男人本色| 男女做爰真人视频直播| 亚洲a∨国产av综合av| 色六月婷婷亚洲婷婷六月| 2019国产品在线视频| 无套内内射视频网站| 全部孕妇毛片| 日韩加勒比一本无码精品| 国产无遮挡又黄又爽网站| 最新精品香蕉在线| 香蕉在线精品视频在线| 天天摸夜夜添狠狠添高潮出水| 少妇富婆高级按摩出水高潮| 唐人社导航福利精品| 国产性猛交普通话对白| 黑人尾随强伦姧人妻爽翻天| 精品国产午夜福利精品推荐| 丁香啪啪综合成人亚洲| 国产亚洲精品久久久久久| 亚洲中文字幕aⅴ无码天堂| 欧美老妇疯狂xxxxbbbb| 波多野美乳人妻hd电影欧美| 成人h动漫精品一区二区| 97色成人综合网站| 精品一区二区三区四区五区六区| 99久久人妻无码精品系列| 精品无码综合一区二区三区| 天堂亚洲国产中文在线| 久久精品午夜福利| 日韩中文高清在线专区 |