在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CAPNS1 Antibody

  • 中文名稱:
    CAPNS1兔多克隆抗體
  • 貨號:
    CSB-PA004503ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004503ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA004503ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CAPNS1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CAPNS1
  • 別名:
    30K antibody; Calcium activated neutral proteinase antibody; Calcium activated neutral proteinase small subunit antibody; Calcium dependent protease small subunit 1 antibody; Calcium dependent protease small subunit antibody; Calcium-activated neutral proteinase small subunit antibody; Calcium-dependent protease small subunit 1 antibody; Calcium-dependent protease small subunit antibody; Calpain 4 antibody; Calpain 4 small subunit (30K) antibody; Calpain 4 small subunit antibody; Calpain regulatory subunit antibody; Calpain S1 antibody; Calpain small polypeptide antibody; Calpain small subunit 1 antibody; Calpain4 antibody; CalpainS1 antibody; CANP antibody; CANP small subunit antibody; CANPS antibody; CAPN 4 antibody; CAPN S1 antibody; CAPN4 antibody; CAPNS 1 antibody; CAPNS antibody; Capns1 antibody; CDPS antibody; CPNS1_HUMAN antibody; CSS 1 antibody; CSS1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Calpain small subunit 1 protein (69-268AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 基因功能參考文獻:
    1. that Capn4 promotes cell proliferation by increasing MAPK7 expression PMID: 29331389
    2. Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. PMID: 29648579
    3. Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. PMID: 29331762
    4. MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. PMID: 28857668
    5. Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. PMID: 27878263
    6. CAPNS1 depletion is coupled to impairment of breast cancer cell growth. PMID: 26771715
    7. High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. PMID: 25636510
    8. HBXIP was able to up-regulate Capn4 at the levels of promoter. PMID: 25304384
    9. The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706
    10. Capn4 can contribute to hepatocellular carcinoma growth and metastasis PMID: 24962955
    11. Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. PMID: 24514433
    12. Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB. PMID: 24703594
    13. This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. PMID: 24297866
    14. Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma PMID: 23349941
    15. The authors conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells. PMID: 20419804
    16. CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress PMID: 20107320
    17. Genetic variations in LEP, CAPNS1 and ALOX15 show significant association with IL-6 expression. PMID: 19942621
    18. calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. PMID: 12121983
    19. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    20. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    21. c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells PMID: 18544539
    22. RasGAP and Capns1 interaction in oncogenic Ras cells is involved in regulating migration and cell survival. PMID: 18761085

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 數據庫鏈接:

    HGNC: 1481

    OMIM: 114170

    KEGG: hsa:826

    STRING: 9606.ENSP00000246533

    UniGene: Hs.515371



主站蜘蛛池模板: 欧美日韩国产中文高清视频| 蜜桃视频网站| 久久亚洲精品国产亚洲老地址| 成人美女黄网站色大色费全看| 国产亚洲日韩在线a不卡| 性无码专区无码| 四虎亚洲中文字幕无码永久 | 香蕉人妻av久久久久天天| 日日碰狠狠躁久久躁96| 9lporm自拍视频区| 国产精品无码无卡在线播放| 中文字幕在线免费看线人| 国产伦精品一区二区三区妓女下载 | 粗了大了 整进去好爽视频| 丝袜美腿丝袜亚洲综合| 色综合a怡红院怡红院| 久久久精品人妻一区二区三区蜜桃| 一区二区三区在线 | 网站| 成人亚洲精品久久99狠狠| 午夜精品影视国产一区在线麻豆 | 亚洲国产精品成人久久蜜臀| 伊人色综合久久天天| 国产免费又色又爽又黄软件| 中文字字幕在线成人av电影| 国产强被迫伦姧在线观看无码| 超碰曰口干天天种夜夜爽| 米奇影院888奇米色99在线| 欧美人妻精品一区二区三区| 亚洲最大日夜无码中文字幕| 清纯唯美经典一区二区| 国模杨依粉嫩蝴蝶150p| 欧美在线 | 亚洲| 成人午夜高潮刺激免费视频| 天天天狠天天碰天天爱| 国产成人精品日本亚洲第一区 | 久久精品国产99久久6动漫| 无码人妻精品一区二区三区下载 | 亚洲精品亚洲人成人网| 婷婷五月俺也去人妻| 亚洲精品国产高清一线久久| 午夜久久久久久禁播电影|