在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

toxB Antibody

Rare Species
  • 中文名稱:
    toxB兔多克隆抗體
  • 貨號:
    CSB-PA321589HA01DUN
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Peptoclostridium difficile toxB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    toxB
  • 別名:
    toxB antibody; tcdB antibody; Toxin B antibody; EC 3.4.22.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Peptoclostridium difficile
  • 免疫原:
    Recombinant Peptoclostridium difficile Toxin B protein (1751-2366AA)
  • 免疫原種屬:
    Peptoclostridium difficile
  • 標記方式:
    Non-conjugated

    本頁面中的產品,toxB Antibody (CSB-PA321589HA01DUN),的標記方式是Non-conjugated。對于toxB Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA321589HB01DUN toxB Antibody, HRP conjugated ELISA
    FITC CSB-PA321589HC01DUN toxB Antibody, FITC conjugated
    Biotin CSB-PA321589HD01DUN toxB Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdB constitutes the main toxin that mediates the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdA, TcdB is more virulent and more important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdB) into the host cytosol. Targets colonic epithelia by binding to the frizzled receptors FZD1, FZD2 and FZD7, and enters host cells via clathrin-mediated endocytosis. Frizzled receptors constitute the major host receptors in the colonic epithelium, but other receptors, such as CSPG4 or NECTIN3/PVRL3, have been identified. Binding to carbohydrates and sulfated glycosaminoglycans on host cells suface also contribute to entry into cells. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (Glucosyltransferase TcdB), which constitutes the active part of the toxin, in the cytosol.; Active form of the toxin, which is released into the host cytosol following autoprocessing and inactivates small GTPases. Acts by mediating monoglucosylation of small GTPases of the Rho family (Rac1, RhoA, RhoB, RhoC, RhoG and Cdc42) in host cells at the conserved threonine residue located in the switch I region ('Thr-37/35'), using UDP-alpha-D-glucose as the sugar donor. Monoglucosylation of host small GTPases completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function.
  • 基因功能參考文獻:
    1. The high susceptibility of enteric glial cell to toxin B in vitro, the increased sensitivity to inflammatory cytokines related to apoptosis and the persistence of altered functions in surviving cells suggest an important in vivo role of enteric glial cell in the pathogenesis of C. difficile infection. PMID: 27891552
  • 亞細胞定位:
    [Toxin B]: Secreted. Host endosome membrane.; [Glucosyltransferase TcdB]: Host cytoplasm, host cytosol. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.


主站蜘蛛池模板: 亚洲人成网站18禁止| 亚洲国产高清在线一区二区三区| 日本无码人妻精品一区二区蜜桃 | 久久综合av色老头免费观看| 99久久人人爽亚洲精品美女| 国产精品久久..4399| 中文乱码人妻系列一区| 无码av片在线观看免费| 波多野结衣乳巨码无在线| 美女裸体无遮挡免费视频网站| 国产精品怡红院在线观看| 日日碰日日摸夜夜爽无码| 野外做受又硬又粗又大视频√| 无码av高潮抽搐流白浆| 免费无码午夜福利片| 国产在线看片无码人精品| 亚洲男人的天堂av手机在线观看 | 无码播放一区二区三区| 亚洲日韩精品欧美一区二区一| 亚洲欧洲日产国码韩国| 骚虎成人免费99xx| 无码办公室丝袜ol中文字幕| 起碰免费公开97在线视频| 久久国产热精品波多野结衣av| 欧美亚洲熟妇一区二区三区| 成人综合婷婷国产精品久久蜜臀| 婷婷久久综合九色综合| 久久激情综合狠狠爱五月| 都市激综合小说区另类区| 在线观看免费人成视频色9| 国产精品毛片完整版视频| 精品一卡2卡3卡4卡新区在线 | 欧美另类 自拍 亚洲 图区| 乱人伦中文字幕成人网站在线| 妺妺窝人体色777777| aaa午夜级特黄日本大片| 欧美午夜精品一区二区蜜桃| 四虎亚洲中文字幕无码永久| 中国内射xxxx6981少妇| 欲香欲色天天综合和网| 大伊香蕉精品视频在线天堂|