在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

toxB Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    toxB兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA321589HB01DUN
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Peptoclostridium difficile toxB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    toxB
  • 別名:
    toxB antibody; tcdB antibody; Toxin B antibody; EC 3.4.22.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Peptoclostridium difficile
  • 免疫原:
    Recombinant Peptoclostridium difficile Toxin B protein (1751-2366AA)
  • 免疫原種屬:
    Peptoclostridium difficile
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdB constitutes the main toxin that mediates the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdA, TcdB is more virulent and more important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdB) into the host cytosol. Targets colonic epithelia by binding to the frizzled receptors FZD1, FZD2 and FZD7, and enters host cells via clathrin-mediated endocytosis. Frizzled receptors constitute the major host receptors in the colonic epithelium, but other receptors, such as CSPG4 or NECTIN3/PVRL3, have been identified. Binding to carbohydrates and sulfated glycosaminoglycans on host cells suface also contribute to entry into cells. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (Glucosyltransferase TcdB), which constitutes the active part of the toxin, in the cytosol.; Active form of the toxin, which is released into the host cytosol following autoprocessing and inactivates small GTPases. Acts by mediating monoglucosylation of small GTPases of the Rho family (Rac1, RhoA, RhoB, RhoC, RhoG and Cdc42) in host cells at the conserved threonine residue located in the switch I region ('Thr-37/35'), using UDP-alpha-D-glucose as the sugar donor. Monoglucosylation of host small GTPases completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function.
  • 基因功能參考文獻:
    1. The high susceptibility of enteric glial cell to toxin B in vitro, the increased sensitivity to inflammatory cytokines related to apoptosis and the persistence of altered functions in surviving cells suggest an important in vivo role of enteric glial cell in the pathogenesis of C. difficile infection. PMID: 27891552
  • 亞細胞定位:
    [Toxin B]: Secreted. Host endosome membrane.; [Glucosyltransferase TcdB]: Host cytoplasm, host cytosol. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.


主站蜘蛛池模板: 午夜精品久久久久9999| 激情综合五月丁香亚洲| 久久久久久无码日韩欧美| 亚洲欧美综合精品成人网| 精品一卡2卡三卡4卡乱码精品视频 | 亚洲级αv无码毛片久久精品| av天堂永久资源网| 蜜桃无码一区二区三区| 亚洲成av人片在线观看无码不卡| 人人超碰人摸人爱| 国产成人av综合久久| 国产精品亚洲精品日韩己满十八小| 日本亚洲vr欧美不卡高清专区| 国产亚洲香蕉线播放αv38| 97国产在线看片免费人成视频| 日本丰满大乳乳液| 国产乱了伦视频大全亚琴影院| 99久久久无码国产精品9| 少妇仑乱a毛片| 免费看又黄又无码的网站| 日日噜噜夜夜狠狠va视频v| 人妻内射一区二区在线视频| 中文乱码人妻系列一区二区| 又粗又猛又黄又爽无遮挡| 久久久久无码精品国产人妻无码| 国产精品国产三级国产an| 国产午夜高清高清在线观看| 99er热精品视频| 久久亚洲精品无码va白人极品| 国模丽丽啪啪一区二区| 18精品久久久无码午夜福利| 色妞精品av一区二区三区| 亚洲精品宾馆在线精品酒店| 亚洲日韩精品无码专区加勒比海| 国产精品久久久久久人妻精品| 桃花色综合影院| 亚洲欧洲av综合色无码| 天堂а√在线最新版中文| 亚洲精品无码久久久久秋霞 | 久久国产色av免费观看| 国产97色在线 | 亚洲|