在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

toxB Antibody, FITC conjugated

Rare Species
  • 中文名稱:
    toxB兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA321589HC01DUN
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Peptoclostridium difficile toxB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    toxB
  • 別名:
    toxB antibody; tcdB antibody; Toxin B antibody; EC 3.4.22.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Peptoclostridium difficile
  • 免疫原:
    Recombinant Peptoclostridium difficile Toxin B protein (1751-2366AA)
  • 免疫原種屬:
    Peptoclostridium difficile
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdB constitutes the main toxin that mediates the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdA, TcdB is more virulent and more important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdB) into the host cytosol. Targets colonic epithelia by binding to the frizzled receptors FZD1, FZD2 and FZD7, and enters host cells via clathrin-mediated endocytosis. Frizzled receptors constitute the major host receptors in the colonic epithelium, but other receptors, such as CSPG4 or NECTIN3/PVRL3, have been identified. Binding to carbohydrates and sulfated glycosaminoglycans on host cells suface also contribute to entry into cells. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (Glucosyltransferase TcdB), which constitutes the active part of the toxin, in the cytosol.; Active form of the toxin, which is released into the host cytosol following autoprocessing and inactivates small GTPases. Acts by mediating monoglucosylation of small GTPases of the Rho family (Rac1, RhoA, RhoB, RhoC, RhoG and Cdc42) in host cells at the conserved threonine residue located in the switch I region ('Thr-37/35'), using UDP-alpha-D-glucose as the sugar donor. Monoglucosylation of host small GTPases completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function.
  • 基因功能參考文獻:
    1. The high susceptibility of enteric glial cell to toxin B in vitro, the increased sensitivity to inflammatory cytokines related to apoptosis and the persistence of altered functions in surviving cells suggest an important in vivo role of enteric glial cell in the pathogenesis of C. difficile infection. PMID: 27891552
  • 亞細胞定位:
    [Toxin B]: Secreted. Host endosome membrane.; [Glucosyltransferase TcdB]: Host cytoplasm, host cytosol. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.


主站蜘蛛池模板: 国产亚洲精品久久久久四川人| 日本乱人伦aⅴ精品| 久久不见久久见免费视频下载| 两个奶头被吃高潮视频| 寂寞少妇做spa按摩无码| 秋霞电影网午夜鲁丝片无码| 在线观看国产丝袜控网站| 中国娇小与黑人巨大交| 久久国产成人精品国产成人亚洲 | 日产精品卡二卡三卡四卡区满十八 | 亚洲一区二区三区中文字幕在线| 一个人看的www片免费高清视频| 日本不卡一区二区三区在线| 国内精品伊人久久久久影院对白| 亚洲精品少妇一区二区| 欧美性猛交aaaa片黑人| 日本丰满熟妇videossex一| 久久天天躁狠狠躁夜夜躁2012| 欧美成年网站色a| 精品深夜av无码一区二区| 青青草av一区二区三区| 永久免费精品成人网站| 少妇又紧又深又湿又爽视频| 人妻内射一区二区在线视频| 久久久久国产精品人妻aⅴ毛片| av永久天堂一区| 国内大量偷窥精品视频| 国产亚洲情侣一区二区无| 97国产超碰一区二区三区| 日韩av无码精品一二三区| 中文字幕无码一区二区免费| 一本久久a久久免费精品不卡| 亚洲中字慕日产2020| 人妻熟女一区| 亚洲乱码一区二三四区ava| 欧美自拍亚洲综合丝袜| 色婷婷综合久色aⅴ五区最新| 奇米精品视频一区二区三区| 午夜三级a三级三点| 玩弄少妇人妻中文字幕| 国产精品永久免费|