在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

toxA Antibody

Rare Species
  • 中文名稱:
    toxA兔多克隆抗體
  • 貨號:
    CSB-PA324524HA01DUN
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Peptoclostridium difficile toxA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    toxA
  • 別名:
    toxA antibody; tcdA antibody; Toxin A antibody; EC 3.4.22.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Peptoclostridium difficile
  • 免疫原:
    Recombinant Peptoclostridium difficile Toxin A protein (2387-2710AA)
  • 免疫原種屬:
    Peptoclostridium difficile
  • 標記方式:
    Non-conjugated

    本頁面中的產品,toxA Antibody (CSB-PA324524HA01DUN),的標記方式是Non-conjugated。對于toxA Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA324524HB01DUN toxA Antibody, HRP conjugated ELISA
    FITC CSB-PA324524HC01DUN toxA Antibody, FITC conjugated
    Biotin CSB-PA324524HD01DUN toxA Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. Binding to LDLR, as well as carbohydrates and sulfated glycosaminoglycans on host cells suface contribute to entry into cells. In contrast to TcdB, Frizzled receptors FZD1, FZD2 and FZD7 do not act as host receptors in the colonic epithelium for TcdA. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (Glucosyltransferase TcdA), which constitutes the active part of the toxin, in the cytosol.; Active form of the toxin, which is released into the host cytosol following autoprocessing and inactivates small GTPases. Acts by mediating monoglucosylation of small GTPases of the Rho family (Rac1, RhoA, RhoB, RhoC, Rap2A and Cdc42) in host cells at the conserved threonine residue located in the switch I region ('Thr-37/35'), using UDP-alpha-D-glucose as the sugar donor. Monoglucosylation of host small GTPases completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function. Also able to catalyze monoglucosylation of some members of the Ras family (H-Ras/HRAS, K-Ras/KRAS and N-Ras/NRAS), but with much less efficiency than with Rho proteins, suggesting that it does not act on Ras proteins in vivo.
  • 亞細胞定位:
    [Toxin A]: Secreted. Host endosome membrane.; [Glucosyltransferase TcdA]: Host cytoplasm, host cytosol. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.


主站蜘蛛池模板: 亚洲成在人网站无码天堂| 夜鲁鲁鲁夜夜综合视频欧美| 久久久亚洲欧洲日产国码农村| 国产精品亚洲一区二区无码| 欧美人与动人物牲交免费观看| 天天爱天天做久久狼狼| 377人体粉嫩噜噜噜| 天天爽夜夜爽人人爽一区二区| 无码专区aaaaaa免费视频| 色悠久久久久综合欧美99| 一本久久伊人热热精品中文字幕 | 波多野结衣乳巨码无在线观看| 国产 一二三四五六| 伊人久久大香线蕉av最新| 亚洲成在人线在线播放无码vr| 国产精品亚洲a∨天堂| 国产美女裸体无遮挡免费视频| 少妇真实被内射视频三四区| 久久香港三级台湾三级播放| 欧美一性一乱一交一免费视频| 2023国产精品一卡2卡三卡4卡| 久久精品国产一区二区三区不卡| 国产乱子轮xxx农村| 成 人色 网 站 欧美大片在线观看| 97成人精品区在线播放| 亚洲综合伊人久久大杳蕉| 久久99国产精品久久99果冻传媒| 777精品出轨人妻国产| 国产av老师丝袜美腿丝袜| 国产农村乱辈无码| 东北女人啪啪对白| 日韩综合夜夜香内射| 麻豆传煤入口免费进入2023| 日日日日做夜夜夜夜做无码| 亚洲色爱图小说专区| 色五月激情五月| 都市激情 在线 亚洲 国产| 亚洲国产激情一区二区三区| 精选国产av精选一区二区三区| 无码熟妇人妻av| 亚洲一卡一卡二新区无人区|