在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

toxA Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    toxA兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA324524HB01DUN
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Peptoclostridium difficile toxA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    toxA
  • 別名:
    toxA antibody; tcdA antibody; Toxin A antibody; EC 3.4.22.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Peptoclostridium difficile
  • 免疫原:
    Recombinant Peptoclostridium difficile Toxin A protein (2387-2710AA)
  • 免疫原種屬:
    Peptoclostridium difficile
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. Binding to LDLR, as well as carbohydrates and sulfated glycosaminoglycans on host cells suface contribute to entry into cells. In contrast to TcdB, Frizzled receptors FZD1, FZD2 and FZD7 do not act as host receptors in the colonic epithelium for TcdA. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (Glucosyltransferase TcdA), which constitutes the active part of the toxin, in the cytosol.; Active form of the toxin, which is released into the host cytosol following autoprocessing and inactivates small GTPases. Acts by mediating monoglucosylation of small GTPases of the Rho family (Rac1, RhoA, RhoB, RhoC, Rap2A and Cdc42) in host cells at the conserved threonine residue located in the switch I region ('Thr-37/35'), using UDP-alpha-D-glucose as the sugar donor. Monoglucosylation of host small GTPases completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption and cell death, resulting in the loss of colonic epithelial barrier function. Also able to catalyze monoglucosylation of some members of the Ras family (H-Ras/HRAS, K-Ras/KRAS and N-Ras/NRAS), but with much less efficiency than with Rho proteins, suggesting that it does not act on Ras proteins in vivo.
  • 亞細胞定位:
    [Toxin A]: Secreted. Host endosome membrane.; [Glucosyltransferase TcdA]: Host cytoplasm, host cytosol. Host cell membrane; Peripheral membrane protein; Cytoplasmic side.


主站蜘蛛池模板: 乱无码伦视频在线观看| 久久久久久毛片免费播放| 十八岁污网站在线观看| 青青草国产免费久久久| 国语少妇高潮对白在线| av永久天堂一区二区三区| 亚洲欧美精品伊人久久| av狼友无码国产在线观看| 亚洲男人的天堂成人www| 国产特级毛片aaaaaa高清| 一区二区三区人妻无码| 人妻巨大乳挤奶水hd免费看| 国产成人一区二区三区免费视频| 精品人伦一区二区三电影| 亚洲国产婷婷六月丁香| 国产精品性夜天天拍拍2021| 久久综合国产乱子伦精品免费| 国产成人精品日本亚洲网站| 内射中出日韩无国产剧情| 玩弄少妇的肉体k8经典| 亚洲人成黄网站69影院| 四虎免费大片aⅴ入口| 色综合久久中文娱乐网| 国产成人美女视频网站| www成人国产高清内射| 国产乱妇乱子视频在播放| 国产精品黄页免费高清在线观看| 精品国际久久久久999波多野| 99精品欧美一区二区三区| 中文无码成人免费视频在线观看 | 秋霞电影网午夜鲁丝片无码| 精品亚洲aⅴ在线无码播放| 两个黑人大战嫩白金发美女| 久久99国产精品成人| 97久久超碰精品视觉盛宴| 伊人久久成综合久久影院| 让少妇高潮无乱码高清在线观看| 内射爽无广熟女亚洲| 奇米精品视频一区二区三区| 日韩加勒比一本无码精品| 成人免费毛片内射美女-百度|