在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ZC3HC1 Antibody

ZC3HC1 Antibody

  • 中文名稱：
    ZC3HC1兔多克隆抗體
  • 貨號：
    CSB-PA003452
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COS7 cells using NIPA Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ZC3HC1
  • 別名：
    hNIPA antibody; NIPA_HUMAN antibody; Nuclear interacting partner of ALK antibody; Nuclear interacting partner of anaplastic lymphoma kinase antibody; Nuclear-interacting partner of ALK antibody; Nuclear-interacting partner of anaplastic lymphoma kinase antibody; zc3hc1 antibody; Zinc finger C3HC type containing 1 antibody; Zinc finger C3HC-type protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from Human NIPA around the non-phosphorylation site of S354.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
  • 基因功能參考文獻：
    1. Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease. PMID: 28115489
    2. This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA. PMID: 27226629
    3. ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort. PMID: 26266351
    4. Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis. PMID: 24286297
    5. The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry. PMID: 16009132
    6. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2). PMID: 22955283
    7. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner PMID: 22205987
    8. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events PMID: 12748172

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
  • 數據庫鏈接：

    HGNC: 29913

    KEGG: hsa:51530

    STRING: 9606.ENSP00000351052

    UniGene: Hs.194157



主站蜘蛛池模板： 伊人久久大香线蕉av网| 国产免费无码一区二区三区| 亚洲夜夜性无码| 国产熟妇搡bbbb搡bbbb| 成av人电影在线观看| 亚洲中文字幕aⅴ无码天堂| 国内揄拍国内精品对白| 久久人午夜亚洲精品无码区| 强奷妇系列中文字幕| 成人婷婷网色偷偷亚洲男人的天堂| 午夜精品一区二区三区的区别| 日日摸日日添日日碰9学生露脸| 国产情侣草莓视频在线| 真人一进一出120秒试看| 蜜桃mv在线播放免费观看视频| 农民人伦一区二区三区| 人妻教师痴汉电车波多野结衣 | 男女做爰真人视频直播| 三上悠亚精品一区二区久久| 日韩卡二卡三卡四卡永久入口| 欧美成 人 网 站 免费| 国产精品免费大片| 国产无遮挡又黄又爽免费网站| 色综合天天无码网站| 无码免费中文字幕视频| 国产精品久久国产精品99| 么公的好大好硬好深好爽视频| 国产边摸边吃奶边做爽视频| 欧美中文亚洲v在线| 国产欧美日本亚洲精品一5区| 怡红院a∨人人爰人人爽| 色偷偷av一区二区三区| 亚洲—本道 在线无码av发| 动漫精品中文无码卡通动漫| 欧美性白人极品hd| 色喜国模李晴超大尺度 | 天天综合网网欲色| 婷婷色香合缴缴情av第三区| 成人h无码动漫超w网站| 国产精品自在拍在线拍| 精品夜夜澡人妻无码av|