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  4. ZC3HC1 Antibody

ZC3HC1 Antibody

  • 中文名稱：
    ZC3HC1兔多克隆抗體
  • 貨號：
    CSB-PA003452
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COS7 cells using NIPA Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ZC3HC1
  • 別名：
    hNIPA antibody; NIPA_HUMAN antibody; Nuclear interacting partner of ALK antibody; Nuclear interacting partner of anaplastic lymphoma kinase antibody; Nuclear-interacting partner of ALK antibody; Nuclear-interacting partner of anaplastic lymphoma kinase antibody; zc3hc1 antibody; Zinc finger C3HC type containing 1 antibody; Zinc finger C3HC-type protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from Human NIPA around the non-phosphorylation site of S354.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
  • 基因功能參考文獻：
    1. Common nonsynonymous coding variant in ZC3HC1 (rs11556924) is associated with protection from coronary artery disease. PMID: 28115489
    2. This study shows that the Coronary Artery Disease-associated coding polymorphism in ZC3HC1 alters the dynamics of cell-cycle regulation by NIPA. PMID: 27226629
    3. ZC3HC1 rs11556924 polymorphism is associated with hypertension in a Finnish cohort. PMID: 26266351
    4. Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis. PMID: 24286297
    5. The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry. PMID: 16009132
    6. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2). PMID: 22955283
    7. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner PMID: 22205987
    8. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events PMID: 12748172

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
  • 數據庫鏈接：

    HGNC: 29913

    KEGG: hsa:51530

    STRING: 9606.ENSP00000351052

    UniGene: Hs.194157



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