在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WDFY3 Antibody

  • 中文名稱:
    WDFY3兔多克隆抗體
  • 貨號:
    CSB-PA025992GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    WDFY3
  • 別名:
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human WDFY3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能參考文獻:
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亞細胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 組織特異性:
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116



主站蜘蛛池模板: 久久精品国产免费观看| av激情亚洲男人的天堂| 六月丁香亚洲综合在线视频| 亚洲欧美人成电影在线观看| 久久亚洲国产精品五月天婷| 久久综合狠狠综合久久综合88| 日韩人妻一区二区三区免费| 无码专区人妻系列日韩精品| 成年轻人电影免费无码 | 最爽爱爱高潮免费视频| 桃花色综合影院| 国产免费无码一区二区视频| 国产传媒麻豆剧精品av国产 | 中日韩精品视频在线观看| 精品久久久久久| 久久久综合亚洲色一区二区三区| 内射巨臀欧美在线视频| 久久婷婷狠狠综合激情| 纯爱无遮挡h肉动漫在线播放| 强睡邻居人妻中文字幕| 成人亚洲欧美一区二区三区| 国产乱人伦av在线麻豆a | 一本加勒比hezyo无码人妻| 久久综合精品国产二区无码| 亚洲人成亚洲精品| 免费无码av片在线观看潮喷| 18禁真人抽搐一进一出免费 | 欧美日韩亚洲国产在线制服| 少妇高潮av久久久久久| 色播久久人人爽人人爽人人片av| 日韩 欧美 国产 一区三| 亚洲中文字幕无码卡通动漫野外 | 国产成人精品视觉盛宴| 亚洲欧洲精品成人久久曰影片| 在线看免费无码av天堂| 欧美日韩免费专区在线| 亚洲成av 人片在线观看无码| 97人妻天天摸天天爽天天| 国产人妻人伦精品1国产丝袜| 亚洲国产成人av片在线播放| 国产三级视频在线播放线观看|