在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WDFY3 Antibody, Biotin conjugated

  • 中文名稱:
    WDFY3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA809030LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WDFY3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDFY3
  • 別名:
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能參考文獻(xiàn):
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亞細(xì)胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 組織特異性:
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116



主站蜘蛛池模板: 18禁裸体女免费观看| 色婷婷六月亚洲综合香蕉| 国产黑色丝袜在线视频| 日韩一本之道一区中文字幕| 色欲天天网站欧美成人福利网| 热99re久久国超精品首页| 久久久精品人妻无码专区不卡| 亚洲日韩v无码中文字幕| 日日做夜狠狠爱欧美黑人| 综合 欧美 小说 另类 图| 欧美性猛交xxxx乱大交3| 日本免费视频| 最新国产aⅴ精品无码| 欧美 亚洲 日韩 中文2019| 欧美人与动牲交a精品| 色狠狠一区二区三区香蕉| 欧美综合自拍亚洲综合区| 久久久久国产精品人妻aⅴ果冻| 无套内谢老熟女| 亚洲国产av玩弄放荡人妇| 午夜人性色福利无码视频在线观看| 人妻丰满熟妇av无码区| 日本高清无卡码一区二区久久| 免费va国产高清大片在线| 日韩不卡1卡2卡三卡2021免费 | 无码中文av有码中文a| 久久人人97超碰a片精品| 中文字幕人妻熟女人妻| 人人色在线视频播放| 18禁男女污污污午夜网站免费暖暖 | 欧美品无码一区二区三区在线蜜桃| 国产av巨作丝袜秘书| 少妇性l交大片欧洲热妇乱xxx| 亚洲高清无在码在线电影不卡 | 熟妇的味道hd中文字幕| 高清不卡毛片免费观看| 日本日本熟妇中文在线视频| 午夜精品久久久久久久| 国产丝袜足j在线视频播放| 人妻系列无码一区二区三区| 日本真人做爰免费视频120秒|