在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WDFY3 Antibody, Biotin conjugated

  • 中文名稱:
    WDFY3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA809030LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WDFY3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDFY3
  • 別名:
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能參考文獻(xiàn):
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亞細(xì)胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 組織特異性:
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116



主站蜘蛛池模板: 日本天天日噜噜噜| 国产丶欧美丶日本不卡视频| 国产色视频一区二区三区qq号 | 无码日日模日日碰夜夜爽| 吃奶揉捏奶头高潮视频| 激情按摩系列片aaaa| 天美麻花果冻视频大全英文版| 三级4级全黄60分钟| 亚洲成在人线av| 乱码人妻一区二区三区| 国产jjzzjjzz视频全部免费| 久草热8精品视频在线观看| 日韩高清在线亚洲专区小说| 国产好大好硬好爽免费视频| 中文字幕亚洲综合久久青草| 免费网站观看www在线观看| 午夜人妻久久久久久久久| 亚洲欧美精品aaaaaa片| 国产精品爱久久久久久久| 曰本女人与公拘交酡| 欧美性黑人极品hd另类| 久久精品人人爽人人爽| 在线 国产 精品 蜜芽| 浓毛欧美老妇乱子伦视频| 国产熟女内射oooo| 久久精品国产99国产精品澳门 | 亚洲va久久久噜噜噜久久4399| 国产色播av在线观看| 日韩精品国产另类专区| 亚洲综合久久无码色噜噜| 亚洲精品成av人片天堂无码| 热re99久久精品国99热| 国产日韩精品一区二区三区在线| 欧美人牲口杂交在线播放免费| 无码ol丝袜高跟秘书在线观看| 亚洲国产欧美中文丝袜日韩| 亚洲日本在线电影| 无码乱人伦一区二区亚洲一| 男人扒开女人双腿猛进视频| av天堂中av世界中文在线播放| 在线看午夜福利片国产|