在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WDFY3 Antibody, FITC conjugated

  • 中文名稱:
    WDFY3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA809030LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WDFY3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDFY3
  • 別名:
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能參考文獻:
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

    顯示更多

    收起更多

  • 相關疾病:
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亞細胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 組織特異性:
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 數據庫鏈接:

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116



主站蜘蛛池模板: 97超碰国产精品无码分类| 精品人妻无码一区二区三区性| 国产女爽爽精品视频天美传媒| 99久无码中文字幕一本久道| 天堂av无码大芭蕉伊人av不卡| 久久精品国产亚洲不av麻豆| 风韵多水的老熟妇| 99精品视频在线观看| 中国国产野外1级毛片视频| 亚洲欧美人成网站在线观看看| 亚洲情a成黄在线观看| 一个人看的www视频免费观看| 五十路亲子中出在线观看| 97性无码区免费| 成人精品v视频在线| 真人作爱免费视频| 久久九九精品99国产精品| 无码av不卡免费播放| 亚洲乱码一区av春药高潮| 波多野结衣50连登视频| 亚洲国产成人精品无码区在线秒播 | 日本高清色本在线www| 99精品视频在线观看免费| 欧美大屁股xxxx高跟欧美黑人| 香蕉噜噜噜噜私人影院| 亚州久久久久区1区2少妇| 热re99久久精品国99热| 久久99精品久久久久婷婷暖| 秋霞在线观看片无码免费不卡| 樱桃视频影视在线观看免费| 久久成人麻豆午夜电影 | 国产做a爱免费视频在线观看| 国产精品9999久久久久 | 国产伦精品一区二区三区妓女下载| 亚洲精品久久国产精品浴池| 亚洲精品国产精品乱码不卡√| 国产精品天干天干综合网| 成人国产片视频在线观看| 亚洲中国精品精华液| 大地资源网第二页免费观看| 人人妻人人爽人人澡欧美一区|