在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WDFY3 Antibody, FITC conjugated

  • 中文名稱:
    WDFY3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA809030LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WDFY3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDFY3
  • 別名:
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能參考文獻:
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

    顯示更多

    收起更多

  • 相關疾病:
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亞細胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 組織特異性:
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 數據庫鏈接:

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116



主站蜘蛛池模板: 国产亚洲日韩av在线播放不卡 | 欧美精品一产区二产区| 在线观看片a免费不卡观看| 裸身美女无遮挡永久免费视频| 好爽…又高潮了毛片免费看| 韩国精品福利一区二区三区| 成人啪啪高潮不断观看 | 色偷偷久久一区二区三区| 精品亚洲欧美无人区乱码| 中文字幕日产无码| 久久精品国产99国产精偷| 久久成人影院精品99| 成人无码av网站在线观看| 国产亚洲精品综合一区| 色婷婷亚洲一区二区三区| 精品少妇人妻av免费久久久| 国产成人免费ā片在线观看老同学| 欧美牲交a欧美牲交aⅴ图片 | 日本强伦姧人妻久久影片| 亚洲人成线无码7777| 国产男女猛烈无遮挡免费视频| 在线视频免费观看爽爽爽| 久久99精品久久久久婷婷暖| 尤物国精品午夜福利视频| 中文字幕制服丝袜第57页| 免费特级黄毛片| 一本加勒比hezyo无码资源网 | 少妇一边呻吟一边说使劲| 久久不见久久见免费视频1′| 免费人成视频19674不收费| 少妇极品熟妇人妻无码| 桃花综合久久久久久久久久网| 日韩免费人妻av无码专区蜜桃| 国产又色又爽又黄的视频在线| 狠狠色综合激情丁香五月| 天堂mv在线mv免费mv香蕉| 玩弄丰满熟妇xxxxx性60| 久久久久久人妻精品一区| 国产成人无码aⅴ片在线观看| 蜜桃av久久久一区二区三区麻豆| 肥白大屁股bbwbbwhd|