在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP36 Antibody

USP36 Antibody

  • 中文名稱：
    USP36兔多克隆抗體
  • 貨號：
    CSB-PA878959LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA878959LA01HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP36 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP36
  • 別名：
    Deubiquitinating enzyme 1 antibody; Deubiquitinating enzyme 36 antibody; DUB1 antibody; FLJ12851 antibody; KIAA1453 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; Ubiquitin specific peptidase 36 antibody; Ubiquitin specific processing protease 36 antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin thiolesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody; UBP36_HUMAN antibody; Usp36 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 protein (670-881AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，USP36 Antibody (CSB-PA878959LA01HU)，的標記方式是Non-conjugated。對于USP36 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA878959LB01HU USP36 Antibody, HRP conjugated ELISA
    FITC CSB-PA878959LC01HU USP36 Antibody, FITC conjugated
    Biotin CSB-PA878959LD01HU USP36 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
  • 基因功能參考文獻：
    1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
    2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
    3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
    4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
    5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
    6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
    7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
    8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
    9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
    10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
    11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
    12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Broadly expressed.
  • 數據庫鏈接：

    HGNC: 20062

    OMIM: 612543

    STRING: 9606.ENSP00000310590

    UniGene: Hs.464243



主站蜘蛛池模板： 免费国产黄网站在线观看可以下载| 国产午夜成人av在线播放| 国产三区在线成人av| 欧美 日产 国产在线观看| 欧美性受xxxxzooz乱毛| 肉色超薄丝袜脚交一区二区| 亚洲精品白浆高清久久久久久 | 777午夜福利理伦电影网| 99精品国产综合久久久久五月天 | 国精品人妻无码一区二区三区喝尿| 精品蜜臀av在线天堂| 天堂网在线www资源| 亚洲色欲色欲大片www无码| 亚洲欧美色一区二区三区| 天天爱天天做天天做天天吃中文 | 亚洲欧美日韩国产精品一区二区| 无码尹人久久相蕉无码| 午夜免费无码福利视频| 国产老妇伦国产熟女老妇高清| 风韵丰满熟妇啪啪区老老熟妇| 99re6热精品视频在线观看| 国产成人久久av免费看| 久久久精品免费| 日本亲近相奷中文字幕| 捆绑白丝粉色jk震动捧喷白浆| 人人妻人人爽人人爽| 鲁丝一区二区三区免费| 在线观看麻豆国产成人av在线播放| 麻豆国产成人av在线播放欲色| 亚洲熟伦熟女新五十路熟妇| 亚洲色播爱爱爱爱爱爱爱| 蜜色欲多人av久久无码| 99精品国产福久久久久久| 欧美最猛黑人xxxx| 国产美女视频免费观看的网站| 一級特黃色毛片免費看| 成人精品视频99在线观看免费| 九九视频国产免| 国产男女免费完整视频在线| 毛片免费视频观看| 中文成人无码精品久久久不卡|