在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP36 Antibody

USP36 Antibody

  • 中文名稱：
    USP36兔多克隆抗體
  • 貨號：
    CSB-PA040096
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    USP36
  • 別名：
    Deubiquitinating enzyme 1 antibody; Deubiquitinating enzyme 36 antibody; DUB1 antibody; FLJ12851 antibody; KIAA1453 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; Ubiquitin specific peptidase 36 antibody; Ubiquitin specific processing protease 36 antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin thiolesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody; UBP36_HUMAN antibody; Usp36 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human USP36.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
  • 基因功能參考文獻(xiàn)：
    1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
    2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
    3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
    4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
    5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
    6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
    7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
    8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
    9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
    10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
    11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
    12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Broadly expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20062

    OMIM: 612543

    STRING: 9606.ENSP00000310590

    UniGene: Hs.464243



主站蜘蛛池模板： 舌头伸进去搅动好爽视频| 日韩美女自卫慰黄网站| 成人h无码动漫超w网站| 国产亚洲精品久久久久的角色| 亚洲成a人片在线不卡一二三区| 97久久久人妻一区精品| 不卡av中文字幕手机看| 国产精品久久久一区二区三区| 亚洲第一区无码专区| av无码东京热亚洲男人的天堂| 国产清纯美女遭强到高潮| 欧美老熟妇乱子| 精品人妻无码专区在线无广告视频| 成 人色 网 站 欧美大片在线观看| 黑人与人妻无码中字视频| 亚洲成a人片在线观看无码| 国产精品无码成人午夜电影| 成人亚欧欧美激情在线观看| 国产亚洲精品自在久久vr| 少妇人妻真实偷人精品视频| 欧美国产综合欧美视频| 辽宁熟女高潮狂叫视频| 欧美xxxx做受视频| 亚洲午夜福利在线观看| 国产精品成人永久在线| 黑人与中国少妇xxxx视频| 国产成人亚洲综合| 真人抽搐一进一出gif| 亚洲无人区午夜福利码高清完整版 | 国产va在线观看免费| 亚洲欧洲av一区二区久久| 蜜臀av999无码精品国产专区| 国产自产v一区二区三区c| 亚洲欧美国产成人综合欲网| 国产精品无码一区二区牛牛| 久久精品青草社区| 日本精品久久久久中文字幕| 在线观看国产午夜福利片| 久碰人妻人妻人妻人妻人掠| 国产嫖妓一区二区三区无码| 国内精品乱码卡一卡2卡三卡新区|