在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP36 Antibody, FITC conjugated

USP36 Antibody, FITC conjugated

  • 中文名稱：
    USP36兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA878959LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP36 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP36
  • 別名：
    Deubiquitinating enzyme 1 antibody; Deubiquitinating enzyme 36 antibody; DUB1 antibody; FLJ12851 antibody; KIAA1453 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; Ubiquitin specific peptidase 36 antibody; Ubiquitin specific processing protease 36 antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin thiolesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody; UBP36_HUMAN antibody; Usp36 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 protein (670-881AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
  • 基因功能參考文獻：
    1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
    2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
    3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
    4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
    5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
    6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
    7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
    8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
    9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
    10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
    11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
    12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Broadly expressed.
  • 數據庫鏈接：

    HGNC: 20062

    OMIM: 612543

    STRING: 9606.ENSP00000310590

    UniGene: Hs.464243



主站蜘蛛池模板： 亚洲性猛交xxxx| 精品国际久久久久999波多野| 伊人久久精品无码av一区| 人妻无码第一区二区三区| 久久欧美国产伦子伦精品| 97人洗澡从澡人人爽人人模| 久久午夜无码鲁丝片直播午夜精品 | 丰满的少妇被猛烈进入白浆| 亚洲aⅴ男人的天堂在线观看| 经典国产乱子伦精品视频| 狠狠色综合久久丁香婷婷| 无码精品一区二区三区免费视频| 色噜噜一区二区三区| 妺妺窝人体色www在线| 久久青青草原精品国产app| 99久久精品国产免费| 亚洲精品一区| 亚洲国产高清在线一区二区三区| 无码被窝影院午夜看片爽爽jk | 无码丰满熟妇juliaann与黑人| 久热国产vs视频在线观看| 中文字幕中文有码在线| 欧美亚洲高清国产| 国产内射爽爽大片视频社区在线| 精品无人区一区二区三区在线| 人妻无码系列一区二区三区| 亚洲国产精品尤物yw在线观看| 成人午夜精品无码区| 亚洲综合在线视频自拍| 国产成人久久综合第一区| 久久精品一区二区三区四区| 亚洲熟女久久色| 男女无遮挡猛进猛出免费观看视频| av人摸人人人澡人人超碰小说| 一本色道久久综合亚洲精品| 国产v在线在线观看视频免费| 无码av免费一区二区三区四区 | 99久久婷婷国产综合精品青草免费 | 少妇爆乳无码专区| 中文幕无线码中文字夫妻| 爆乳护士一区二区三区在线播放|