在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP11 Antibody

USP11 Antibody

  • 中文名稱：
    USP11兔多克隆抗體
  • 貨號：
    CSB-PA006357
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using USP11 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 11 antibody; Ubiquitin carboxyl-terminal hydrolase 11 antibody; Ubiquitin carboxyl-terminal hydrolase X linked antibody; ubiquitin specific peptidase 11 antibody; Ubiquitin specific protease 11 antibody; Ubiquitin thiolesterase 11 antibody; Ubiquitin-specific-processing protease 11 antibody; UBP11_HUMAN antibody; UHX1 antibody; USP11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human USP11.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
  • 基因功能參考文獻：
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11-p21 axis in regulating cell-cycle progression and DNA damage responses. PMID: 29666278
    3. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA) PMID: 29293652
    4. High USP11 expression is associated with cancer. PMID: 26919101
    5. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling. PMID: 27853171
    6. We demonstrated that, while depletion of XIAP attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP. PMID: 28040451
    7. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 and USP11 to maintain the proper status of ubiquitylation gammaH2AX to repair double strand breaks. PMID: 26507658
    8. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR. PMID: 25969536
    9. PML degradation mechanism through Notch/Hey1-induced repression of USP11 involved in brain tumour pathogenesis PMID: 24487962
    10. USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage PMID: 25471832
    11. Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity. PMID: 24724799
    12. USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes. PMID: 23337751
    13. USP11 augments TGFbeta signalling by deubiquitylating ALK5. PMID: 22773947
    14. Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism. PMID: 19874889
    15. structural and functional characterization of the USP11 deubiquitinating enzyme PMID: 12084015
    16. Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination. PMID: 15314155
    17. the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. PMID: 17897950
    18. USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7. PMID: 18408009

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    Peptidase C19 family
  • 數據庫鏈接：

    HGNC: 12609

    OMIM: 300050

    KEGG: hsa:8237

    STRING: 9606.ENSP00000218348

    UniGene: Hs.171501



主站蜘蛛池模板： 亚洲成av人在线视猫咪| 男ji大巴进入女人的视频| 精品无码国产自产拍在线观看蜜| 久久香综合精品久久伊人| 久久―日本道色综合久久| 天堂网在线观看| 久久精品国产精品亚洲| 天天狠天天透天干天干| 国产午夜精品一二区理论影院| 国产精品永久久久久久久久久| 国产精品久久国产精品99 gif| 亚洲成年网站青青草原| 久久久精品人妻一区二区三区gv| 777天堂麻豆爱综合视频| 国产女人的高潮国语对白| 日韩在线一区二区不卡视频| 国产拍揄自揄免费观看| 国产午夜福利视频在线观看| 欧美亚洲一区二区三区| 无码av岛国片在线播放| 国产欧美亚洲日韩图片| 日出水了特别黄的视频| 久久免费精品国产72精品| 日韩欧美偷拍高跟鞋精品一区| 精品国产一区二区三区无码| 一二三四免费观看在线视频中文版| 国产午夜成人无码免费看不卡| 国产老熟女狂叫对白| 无码精品人妻一区二区三区影院 | 92国产精品午夜福利| 久久婷婷综合激情亚洲狠狠| 久久久久国色av∨免费看| 国产裸拍裸体视频在线观看| 内射老妇bbwx0c0ck| 国产在线视频精品视频| 欧美国产亚洲日韩在线二区| 国产美女牲交视频| 中文字幕无码免费不卡视频| 亚洲精品午夜一区人人爽| 人妻av中文字幕久久| 美女张开腿黄网站免费下载|