在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP11 Antibody

USP11 Antibody

  • 中文名稱：
    USP11兔多克隆抗體
  • 貨號：
    CSB-PA006357
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using USP11 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 11 antibody; Ubiquitin carboxyl-terminal hydrolase 11 antibody; Ubiquitin carboxyl-terminal hydrolase X linked antibody; ubiquitin specific peptidase 11 antibody; Ubiquitin specific protease 11 antibody; Ubiquitin thiolesterase 11 antibody; Ubiquitin-specific-processing protease 11 antibody; UBP11_HUMAN antibody; UHX1 antibody; USP11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human USP11.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
  • 基因功能參考文獻：
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11-p21 axis in regulating cell-cycle progression and DNA damage responses. PMID: 29666278
    3. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA) PMID: 29293652
    4. High USP11 expression is associated with cancer. PMID: 26919101
    5. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling. PMID: 27853171
    6. We demonstrated that, while depletion of XIAP attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP. PMID: 28040451
    7. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 and USP11 to maintain the proper status of ubiquitylation gammaH2AX to repair double strand breaks. PMID: 26507658
    8. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR. PMID: 25969536
    9. PML degradation mechanism through Notch/Hey1-induced repression of USP11 involved in brain tumour pathogenesis PMID: 24487962
    10. USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage PMID: 25471832
    11. Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity. PMID: 24724799
    12. USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes. PMID: 23337751
    13. USP11 augments TGFbeta signalling by deubiquitylating ALK5. PMID: 22773947
    14. Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism. PMID: 19874889
    15. structural and functional characterization of the USP11 deubiquitinating enzyme PMID: 12084015
    16. Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination. PMID: 15314155
    17. the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. PMID: 17897950
    18. USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7. PMID: 18408009

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    Peptidase C19 family
  • 數據庫鏈接：

    HGNC: 12609

    OMIM: 300050

    KEGG: hsa:8237

    STRING: 9606.ENSP00000218348

    UniGene: Hs.171501



主站蜘蛛池模板： 免费福利视频一区二区三区高清| 九色porny丨自拍视频| 国产熟睡乱子伦午夜视频麻豆| 成人影院yy111111在线观看| 亚洲精品国产suv| 久久久久人妻精品一区蜜桃| 老司机无码精品a| а√天堂资源中文在线官网| 色综合欧美亚洲国产| 日本午夜免a费看大片中文4| 成人无码a∨电影免费| 国产精品无码一区二区在线观一| 欧美牲交40_50a欧美牲交aⅴ| 人妻中文字幕av无码专区| 亚洲色欲www综合网| 日本天天黄网站| 无码人妻天天拍夜夜爽| 午夜少妇性影院私人影院在线 | 一本久道久久综合久久爱| 四虎国产精品永久地址49| 国产香蕉尹人在线观看视频| 中文字幕色av一区二区三区| 亚洲国产精品18久久久久久| 国产在线观看超清无码视频一区二区 | 学生妹亚洲一区二区| 人妻无码中文字幕免费视频蜜桃| 国产av一区二区精品凹凸| 无码一卡二卡三卡四卡| 色偷偷偷在线视频播放| 丰满多毛的大隂户视频| 性欧美疯狂xxxxbbbb| 精品国产v无码大片在线观看| av无码免费岛国动作片不卡| 亚洲精品无码永久在线观看性色| 成人欧美一区在线视频| 国产偷久久久精品专区| 亚洲欧美日韩另类精品一区| 农村欧美丰满熟妇xxxx| 国色天香成人网| 婷婷五月俺也去人妻| 蜜桃av蜜臀av色欲av麻|