在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

USP11 Antibody

  • 中文名稱:
    USP11兔多克隆抗體
  • 貨號:
    CSB-PA025698GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Deubiquitinating enzyme 11 antibody; Ubiquitin carboxyl-terminal hydrolase 11 antibody; Ubiquitin carboxyl-terminal hydrolase X linked antibody; ubiquitin specific peptidase 11 antibody; Ubiquitin specific protease 11 antibody; Ubiquitin thiolesterase 11 antibody; Ubiquitin-specific-processing protease 11 antibody; UBP11_HUMAN antibody; UHX1 antibody; USP11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human USP11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
  • 基因功能參考文獻:
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11-p21 axis in regulating cell-cycle progression and DNA damage responses. PMID: 29666278
    3. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA) PMID: 29293652
    4. High USP11 expression is associated with cancer. PMID: 26919101
    5. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling. PMID: 27853171
    6. We demonstrated that, while depletion of XIAP attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP. PMID: 28040451
    7. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 and USP11 to maintain the proper status of ubiquitylation gammaH2AX to repair double strand breaks. PMID: 26507658
    8. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR. PMID: 25969536
    9. PML degradation mechanism through Notch/Hey1-induced repression of USP11 involved in brain tumour pathogenesis PMID: 24487962
    10. USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage PMID: 25471832
    11. Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity. PMID: 24724799
    12. USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes. PMID: 23337751
    13. USP11 augments TGFbeta signalling by deubiquitylating ALK5. PMID: 22773947
    14. Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism. PMID: 19874889
    15. structural and functional characterization of the USP11 deubiquitinating enzyme PMID: 12084015
    16. Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination. PMID: 15314155
    17. the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. PMID: 17897950
    18. USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7. PMID: 18408009

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族:
    Peptidase C19 family
  • 數據庫鏈接:

    HGNC: 12609

    OMIM: 300050

    KEGG: hsa:8237

    STRING: 9606.ENSP00000218348

    UniGene: Hs.171501



主站蜘蛛池模板: 亚洲码欧美码一区二区三区| 国产成人欧美日韩在线电影| 日韩亚洲国产高清免费视频| 亚洲综合av一区二区三区| 久久精品这里热有精品| 日韩精品无码中文字幕一区二区| 亚洲综合网站久久久| 免费人成视频| 麻豆一区二区三区精品视频| 日韩人妻熟女中文字幕aⅴ春菜| 亚洲婷婷五月激情综合app| 亚洲学生妹高清av| 亚洲欧美日韩国产成人精品影院| 国产精品被窝福利一区| 国产福利酱国产一区二区| 免费网站观看www在线观看| 女人与拘性猛交视频| 精品日产卡一卡二卡麻豆| 国产女人叫床高潮大片| 人妻夜夜添夜夜无码av | 国内精品伊人久久久久7777| 国产精品国语对白露脸在线播放 | а√在线中文网新版地址在线| 精品国产乱码久久久人妻| 女人裸露免费视频无遮挡网站| 黑色丝袜无码中中文字幕| 天天躁日日躁狠狠躁av麻豆| 99久久精品无码一区二区毛片| 国产精品嫩草影院免费观看| 波多野结衣办公室33分钟| 中文字幕亚洲日韩无线码| 麻豆精品人妻一区二区三区蜜桃| 国产啪视频1000部免费| 色婷婷美国农夫综合激情亚洲| 国产又色又爽又黄好看的视频 | 国产亚洲精品久久77777| 欧美又大又硬又粗bbbbb| 无码精品久久一区二区三区| 69国产精品成人aaaaa片| 中文字幕无码第1页| 欧美肥熟妇xxxxx|