在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP11 Antibody

USP11 Antibody

  • 中文名稱：
    USP11兔多克隆抗體
  • 貨號(hào)：
    CSB-PA986850
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from 293 cells, using USP11 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) USP11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Internal of Human USP11.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
  • 基因功能參考文獻(xiàn)：
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11-p21 axis in regulating cell-cycle progression and DNA damage responses. PMID: 29666278
    3. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA) PMID: 29293652
    4. High USP11 expression is associated with cancer. PMID: 26919101
    5. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling. PMID: 27853171
    6. We demonstrated that, while depletion of XIAP attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP. PMID: 28040451
    7. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 and USP11 to maintain the proper status of ubiquitylation gammaH2AX to repair double strand breaks. PMID: 26507658
    8. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR. PMID: 25969536
    9. PML degradation mechanism through Notch/Hey1-induced repression of USP11 involved in brain tumour pathogenesis PMID: 24487962
    10. USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage PMID: 25471832
    11. Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity. PMID: 24724799
    12. USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes. PMID: 23337751
    13. USP11 augments TGFbeta signalling by deubiquitylating ALK5. PMID: 22773947
    14. Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism. PMID: 19874889
    15. structural and functional characterization of the USP11 deubiquitinating enzyme PMID: 12084015
    16. Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination. PMID: 15314155
    17. the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. PMID: 17897950
    18. USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7. PMID: 18408009

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    Peptidase C19 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12609

    OMIM: 300050

    KEGG: hsa:8237

    STRING: 9606.ENSP00000218348

    UniGene: Hs.171501



主站蜘蛛池模板： 色欲来吧来吧天天综合网| 天天操夜夜操| 少女韩国电视剧在线观看完整| 图片区小说区激情区偷拍区 | 国产舌乚八伦偷品w中| 国产精品亚洲а∨无码播放| 国产内射在线激情一区| 色一情一乱一乱一区99av白浆| 青青草国产成人99久久| 亚洲香蕉视频天天爽| 午夜爽爽爽男女污污污网站| 国产精品av一区二区三区不卡蜜| 欧美超级乱婬视频播放| 九色九九九老阿姨| 夜夜躁狠狠躁日日躁202| 成人无码a∨电影免费| 久久av无码αv高潮αv喷吹| 乱亲女h秽乱长久久久| 国产综合有码无码视频在线 | 337p日本欧洲亚洲大胆精筑 | 久久中文字幕人妻熟av女蜜柚m | 欧美老妇交乱视频在线观看| 久久婷婷激情综合色综合俺也去| 国产成人精品久久一区二区| 欧美天天拍在线视频| 水蜜桃色314在线观看| 中文字幕热久久久久久久| 久久国产免费观看精品3| 亚洲线精品一区二区三区影音先锋 | 久久久精品日本一区二区三区| 水蜜桃av无码| 亚洲男人片片在线观看| 国产av午夜精品一区二区三区| 欧美日韩在线视频| 在线观看免费网页欧美成| 亚洲欧洲日产无码中文字幕| 野花社区在线观看视频| 无码日本精品xxxxxxxxx| 成年女人午夜性视频| 久久av无码精品人妻出轨| 欧美金妇欧美乱妇xxxx|