在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXK Antibody

  • 中文名稱:
    TXK兔多克隆抗體
  • 貨號(hào):
    CSB-PA025362GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BTKL antibody; EC 2.7.10.2 antibody; MGC22473 antibody; Protein-tyrosine kinase 4 antibody; PSCTK5 antibody; PTK4 antibody; Resting lymphocyte kinase antibody; RLK antibody; TKL antibody; TXK antibody; TXK tyrosine kinase antibody; TXK_HUMAN antibody; Tyrosine protein kinase TXK antibody; Tyrosine-protein kinase TXK antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human TXK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC,IF
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
  • 基因功能參考文獻(xiàn):
    1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. PMID: 25593320
    2. fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription PMID: 11859127
    3. Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease. PMID: 16809408
    4. Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses. PMID: 18941202
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
  • 組織特異性:
    Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12434

    OMIM: 600058

    KEGG: hsa:7294

    STRING: 9606.ENSP00000264316

    UniGene: Hs.479669



主站蜘蛛池模板: 色惰日本视频网站www| 精品www日韩熟女人妻| 成人免费视频在线观看| 男女做爽爽爽视频免费软件| 亚洲男人的天堂成人www| 少妇久久久久久被弄高潮 | 视频二区丝袜国产欧美日韩| 人人超碰人人爱超碰国产| 999国产精品999久久久久久| 美女mm131爽爽爽作爱| 国产免费久久精品99reswag | 曰韩人妻无码一区二区三区综合部| 台湾佬中文娱乐22vvvv| 亚洲国产精品日本无码网站| 国产 中文 制服丝袜 另类| 国产人与zoxxxx另类| 国产69精品久久久久777| av色国产色拍| 日韩精品久久久免费观看| 五月丁香啪啪| 无码午夜成人1000部免费视频| 不卡av中文字幕手机看| 狠狠色色综合网站| 国产乱人伦在线播放| 精品久久一区二区乱码| 亚洲欧美国产制服图片区| 亚洲人成网站在线观看69影院 | 亚洲成av人片不卡无码久久 | 与子敌伦刺激对白播放| 国产精品久久久久久无码| av在线亚洲欧洲日产一区二区| 亚洲第一无码av无码专区| 无遮挡裸体免费视频尤物| 日韩 欧美 国产 一区三| 亚洲精品国产成人无码区a片| 精品无人码麻豆乱码1区2区 | 真人做作爱视频| 女人夜夜春高潮爽a∨片| 免费国精产品wnw2544| 西西人体大胆午夜啪啪| 国产99久久久国产无需播放器|