在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXK Antibody, HRP conjugated

  • 中文名稱:
    TXK兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA025362LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TXK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BTKL antibody; EC 2.7.10.2 antibody; MGC22473 antibody; Protein-tyrosine kinase 4 antibody; PSCTK5 antibody; PTK4 antibody; Resting lymphocyte kinase antibody; RLK antibody; TKL antibody; TXK antibody; TXK tyrosine kinase antibody; TXK_HUMAN antibody; Tyrosine protein kinase TXK antibody; Tyrosine-protein kinase TXK antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tyrosine-protein kinase TXK protein (32-83AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
  • 基因功能參考文獻:
    1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. PMID: 25593320
    2. fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription PMID: 11859127
    3. Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease. PMID: 16809408
    4. Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses. PMID: 18941202
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
  • 組織特異性:
    Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.
  • 數據庫鏈接:

    HGNC: 12434

    OMIM: 600058

    KEGG: hsa:7294

    STRING: 9606.ENSP00000264316

    UniGene: Hs.479669



主站蜘蛛池模板: 精品国产小视频在线观看 | 人妻丰满熟妇岳av无码区hd| 亚洲成a人v影院色老汉影院| 99国产精品久久久蜜芽| 女学生14毛片视频片二毛| 999精品无码a片在线1级| 久久不见久久见免费影院3| 精品三级av无码一区| 中国性欧美videofree精品| 吃奶揉捏奶头高潮视频| 成人艳情一二三区| 国产精品亚洲一区二区三区喷水| 狠狠躁夜夜躁无码中文字幕| 天堂中文在线8最新版地址| 成人天堂婷婷青青视频在线观看 | 一二三四视频社区3在线高清| 亚洲一线二线三线品牌精华液久久久| 人妻少妇偷人精品视频| 中文字幕欧美人妻精品一区| 国产人无码a在线西瓜影音| 国产成人18黄网站| 成人精品视频99在线观看免费| 与子敌伦刺激对白播放的优点| 国产成人亚洲无吗淙合青草| 性欧美老妇另类xxxx| 丰满多毛的大隂户视频| 国产超薄肉色丝袜视频| av无码中出一区二区三区| 国产精品毛片无码| 久久www成人_看片免费不卡| 日日日日做夜夜夜夜做无码| 亚洲蜜桃v妇女| 无码中文字幕日韩专区| 国产成人精品三级在线影院| 精品亚洲aⅴ无码一区二区三区| 欧洲成人一区二区三区| 色欲天天婬色婬香综合网完整版 | 极品粉嫩福利午夜在线播放 | 中文字幕日本六区小电影| 国产成人啪精品视频免费网站软件| 亚洲精品国男人在线视频|