在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TXK Antibody, Biotin conjugated

  • 中文名稱:
    TXK兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA025362LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TXK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BTKL antibody; EC 2.7.10.2 antibody; MGC22473 antibody; Protein-tyrosine kinase 4 antibody; PSCTK5 antibody; PTK4 antibody; Resting lymphocyte kinase antibody; RLK antibody; TKL antibody; TXK antibody; TXK tyrosine kinase antibody; TXK_HUMAN antibody; Tyrosine protein kinase TXK antibody; Tyrosine-protein kinase TXK antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tyrosine-protein kinase TXK protein (32-83AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
  • 基因功能參考文獻:
    1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. PMID: 25593320
    2. fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription PMID: 11859127
    3. Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease. PMID: 16809408
    4. Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses. PMID: 18941202
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
  • 組織特異性:
    Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.
  • 數據庫鏈接:

    HGNC: 12434

    OMIM: 600058

    KEGG: hsa:7294

    STRING: 9606.ENSP00000264316

    UniGene: Hs.479669



主站蜘蛛池模板: 四虎国产精品永久在线观看| 东京热一区二区三区无码视频| 国产h视频在线观看| 久久亚洲美女精品国产精品| 精品国产综合成人亚洲区| 免费网禁国产you女网站下载| 2021无码天堂在线| 国产人妻大战黑人20p| 国産精品久久久久久久| 奇米影视777四色狠狠| 国产精品成人片在线观看| 茄子在线看片免费人成视频| 久久久久久久久久久综合日本| 国产黄大片在线观看| 老妇肥熟凸凹丰满刺激| 中出あ人妻熟女中文字幕| 亚洲成αv人片在线观看| 国产一卡二卡三卡四卡视频版| 亚洲成av人无码综合在线观看| 各处沟厕大尺度偷拍女厕嘘嘘| 色综合视频一区中文字幕| 免费人成黄页在线观看国产| 国产在线精品一区在线观看| 伦伦影院午夜理论片| 十八岁污网站在线观看| 国产免费人成视频在线播放播| 日韩在线 | 中文| 无码熟妇人妻av在线电影| 中文字幕无线码| 动漫精品专区一区二区三区不卡| 无码三级av电影在线观看| 亚洲国产婷婷综合在线精品| 欧美激情性做爰免费视频| 欧美亅性猛交内射| 日韩欧美tⅴ一中文字暮| 免免费国产aaaaa片| 乱妇乱女熟妇熟女网站| 国产精品亚洲精品日韩己满十八小| 亚洲精品少妇高清30p| 67194熟妇在线观看线路1 | 成 人 网 站 免费观看|